G1 期细胞周期蛋白、p21 和 Rb 蛋白在结肠癌患者中的预后价值。
The Prognostic Value of G1 Cyclins, p21 and Rb Protein in Patients With Colon Cancer.
机构信息
2nd Department of Propedeutic Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
University Department of Surgery, General and Oncologic Hospital of Kifissia 'Agii Anargiri', Athens, Greece
出版信息
Anticancer Res. 2019 Nov;39(11):6291-6297. doi: 10.21873/anticanres.13839.
BACKGROUND/AIM: Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated the prognostic significance of G1 cyclins, p21 and pRb in tumor proliferation.
PATIENTS AND METHODS
A total of 102 patients with colon cancer were operated on and staged according to TNM. Follow-up was 2 to 68 months (mean 38.3±16.7 months). Expression of cyclin E and D1 were evaluated using immunohistochemistry.
RESULTS
Levels of cyclin E expression were correlated with cyclin D1 expression (p=0.038), p21 expression (p=0.047), and pRb expression (p=0.004). The 5-year survival rate along with prognosis of patients with advanced stage (III, IV) colon cancer and cyclin D1 positive tumors, were significantly worse (p=0.009). Statistically significant association was observed between tumor proliferative capacity Ki-67, cyclin D1 (p=0.009), pRb (p=0.031) and p21 (p=0.050).
CONCLUSION
Cyclin D1 is highly expressed in advanced stage colon cancer patients, implying a potential prognostic value.
背景/目的：细胞周期蛋白 D1 和 E 在细胞周期中发挥不同的作用。细胞周期蛋白 E 促进染色体不稳定性，而细胞周期蛋白 D1 调节细胞凋亡。本研究评估了 G1 细胞周期蛋白、p21 和 pRb 在肿瘤增殖中的预后意义。
患者和方法
对 102 例结肠癌患者进行手术，并根据 TNM 分期。随访时间为 2 至 68 个月（平均 38.3±16.7 个月）。使用免疫组织化学评估细胞周期蛋白 E 和 D1 的表达。
结果
细胞周期蛋白 E 的表达水平与细胞周期蛋白 D1 的表达（p=0.038）、p21 的表达（p=0.047）和 pRb 的表达（p=0.004）相关。晚期（III、IV 期）结肠癌和细胞周期蛋白 D1 阳性肿瘤患者的 5 年生存率和预后明显更差（p=0.009）。肿瘤增殖能力 Ki-67、细胞周期蛋白 D1（p=0.009）、pRb（p=0.031）和 p21（p=0.050）之间存在显著的相关性。
结论
细胞周期蛋白 D1 在晚期结肠癌患者中高表达，提示其具有潜在的预后价值。
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