Department of Radiology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Anticancer Res. 2019 Nov;39(11):6299-6305. doi: 10.21873/anticanres.13840.
BACKGROUND/AIM: A minority of grade I meningiomas (MG1s) recur after surgical resection and their progression is associated with high grade transformation (HGT). This study aimed to characterize the clinicoradiological features of recurrent MGs (RMG) with HGT.
We identified 17 patients diagnosed with MG1 who then underwent surgery for RMG. Patients were categorized into HGT group vs. non-HGT (nHGT) group based on RMG histological grade and clinicoradiological features were comparatively analyzed.
HGT was observed in 41.4% of RMGs. Original tumor size was larger in the HGT group and recurrence time interval was shorter. Following recurrence, 57.1% in the HGT group experienced further disease progression, compared to 22.2% in the nHGT group.
A considerable HGT rate in RMGs developed after MG1 was observed. Although HGT was not distinguished from nHGT by radiological features, HGT in RMG was associated with larger initial tumor size and shorter recurrence time interval.
背景/目的：少数一级脑膜瘤（MG1）在手术后会复发，其进展与高级别转化（HGT）有关。本研究旨在描述具有 HGT 的复发性脑膜瘤（RMG）的临床影像学特征。
我们确定了 17 名诊断为 MG1 的患者，随后对其进行了 RMG 的手术治疗。根据 RMG 的组织学分级，将患者分为 HGT 组和非 HGT（nHGT）组，并比较分析了临床影像学特征。
HGT 见于 41.4%的 RMG。HGT 组的原始肿瘤大小更大，复发时间间隔更短。复发后，HGT 组中有 57.1%的患者进一步发生疾病进展，而 nHGT 组仅有 22.2%的患者发生。
MG1 后发生的 RMG 中存在相当高的 HGT 发生率。尽管 HGT 不能通过影像学特征与 nHGT 区分，但 RMG 中的 HGT 与更大的初始肿瘤大小和更短的复发时间间隔相关。
