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BGP-15 可保护急性乙酰氨基酚过量诱导的肝损伤中的线粒体。

BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury.

机构信息

Department of Medical Chemistry, Semmelweis University, Budapest, Hungary.

2nd Department of Pathology, Semmelweis University, Üllői út 93, Budapest, H-1091, Hungary.

出版信息

Pathol Oncol Res. 2020 Jul;26(3):1797-1803. doi: 10.1007/s12253-019-00721-1. Epub 2019 Nov 8.

DOI:10.1007/s12253-019-00721-1
PMID:31705481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7297855/
Abstract

Acetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress. BGP-15, a hydroximic acid derivative, has been reported to have hepatoprotective effects in APAP overdose induced liver damage. Effect of BGP-15 was further investigated on mitochondria in APAP-overdose induced acute liver injury in mice. We found that BGP-15 efficiently preserved mitochondrial morphology, and it caused a marked decrease in the number of damaged mitochondria. Attenuation of mitochondrial damage by BGP-15 is supported by immunohistochemistry as the TOMM20 label and the co-localized autophagy markers detected in the livers of APAP-treated mice were markedly reduced upon BGP-15 administration. This effect, along with the observed prevention of JNK activation likely contribute to the mitochondrial protective action of BGP-15.

摘要

对乙酰氨基酚（APAP）诱导的肝毒性涉及 c-Jun 氨基末端激酶（JNK）的激活、线粒体损伤和内质网应激。BGP-15 是一种羟肟酸衍生物，据报道在 APAP 过量诱导的肝损伤中有肝保护作用。本研究进一步研究了 BGP-15 对 APAP 过量诱导的急性肝损伤小鼠线粒体的影响。我们发现 BGP-15 能有效地保持线粒体形态，显著减少受损线粒体的数量。BGP-15 减轻线粒体损伤的作用得到免疫组化的支持，因为在 APAP 处理的小鼠肝脏中，TOMM20 标记和共定位的自噬标记明显减少。这种作用，以及观察到的 JNK 激活的抑制，可能有助于 BGP-15 的线粒体保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/26e9509d63db/12253_2019_721_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/570e5db45017/12253_2019_721_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/399fac7a91ef/12253_2019_721_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/70874766a1d4/12253_2019_721_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/a03714b83d40/12253_2019_721_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/26e9509d63db/12253_2019_721_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/570e5db45017/12253_2019_721_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/399fac7a91ef/12253_2019_721_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/70874766a1d4/12253_2019_721_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/a03714b83d40/12253_2019_721_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e994/7297855/26e9509d63db/12253_2019_721_Fig5_HTML.jpg

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2
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Dig Dis. 2015;33(4):464-71. doi: 10.1159/000374090. Epub 2015 Jul 6.
3
Ferroptosis is Involved in Acetaminophen Induced Cell Death.铁死亡参与对乙酰氨基酚诱导的细胞死亡。
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Int J Mol Sci. 2020 Mar 19;21(6):2124. doi: 10.3390/ijms21062124.
4
Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis.慢性丙型肝炎和自身免疫性肝炎中的自噬、线粒体自噬和 microRNA 表达。
Pathol Oncol Res. 2020 Oct;26(4):2143-2151. doi: 10.1007/s12253-020-00799-y. Epub 2020 Mar 2.
Pathol Oncol Res. 2015 Sep;21(4):1115-21. doi: 10.1007/s12253-015-9946-3. Epub 2015 May 12.
4
Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors.肥胖母亲卵母细胞中的线粒体功能障碍：向后代的传递及内质网应激抑制剂的药理学逆转作用
Development. 2015 Feb 15;142(4):681-91. doi: 10.1242/dev.114850.
5
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6
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8
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10
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