Choo Il Han, Chong Ari, Chung Ji Yeon, Kim Hoowon
Department of Neuropsychiatry, Chosun University and Chosun University Hospital, Gwangju, Republic of Korea.
Department of Nuclear Medicine, Chosun University and Chosun University Hospital, Gwangju, Republic of Korea.
J Alzheimers Dis. 2019;72(4):1261-1268. doi: 10.3233/JAD-190816.
Subjective memory complaints (SMC) are a risk factor for Alzheimer's disease.
We aimed to explore the association between SMC and regional amyloid-β (Aβ) deposition in mild cognitive impairment (MCI).
Sixty-eight individuals with MCI were recruited. [18F]Florbetaben PET scans were performed. T1-weighted 3D volumes were also acquired for co-registration with PET and for defining the regions of interest (ROI). Two step exploratory partial correlation analyses between SMC and Aβ deposition were performed with covariates of age, sex, education, and depression. Furthermore, for the priori ROI that had the most significant partial correlation, we investigated the correlation between the SMC and regional Aβ burden using a multiple linear regression model controlling for depression, age, sex, and education.
Significant positive correlations between the SMC and Aβ burden was found in the medial temporal ROI (first step) and in the left parahippocampus ROI (second step). In the priori left parahippocampus, we found significant correlation between the SMC and Aβ burden (R2 = 0.473, p = 0.014).
Our study suggested that the SMC was associated with amyloid accumulation, especially in the left parahippocampus, in individuals with MCI.
主观记忆抱怨（SMC）是阿尔茨海默病的一个风险因素。
我们旨在探讨轻度认知障碍（MCI）患者中SMC与局部淀粉样β蛋白（Aβ）沉积之间的关联。
招募了68名MCI患者。进行了[18F]氟代贝他苯PET扫描。还获取了T1加权3D容积图像，用于与PET图像进行配准以及定义感兴趣区域（ROI）。在控制年龄、性别、教育程度和抑郁等协变量的情况下，对SMC与Aβ沉积进行了两步探索性偏相关分析。此外，对于偏相关性最显著的先验ROI，我们使用控制抑郁、年龄、性别和教育程度的多元线性回归模型，研究了SMC与局部Aβ负荷之间的相关性。
在内侧颞叶ROI（第一步）和左侧海马旁回ROI（第二步）中发现SMC与Aβ负荷之间存在显著正相关。在左侧海马旁回先验区域，我们发现SMC与Aβ负荷之间存在显著相关性（R2 = 0.473，p = 0.014）。
我们的研究表明，MCI患者的SMC与淀粉样蛋白积累有关，尤其是在左侧海马旁回。
