Physical Therapy Department, Instituto de Ciências da Saúde, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon s/n - Vale do Canela Salvador, Salvador, Bahia, CEP 40.110-100, Brazil.
Programa de Pós-Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil.
Curr Atheroscler Rep. 2019 Nov 9;21(11):45. doi: 10.1007/s11883-019-0806-6.
The aim of this study was to determine the effects of aerobic exercise on peak oxygen uptake (peak VO), minute ventilation/carbon dioxide production (VE/VCO slope), and health-related quality of life (HRQoL) among patients with heart failure (HF) and preserved ejection fraction (HFpEF).
We conducted a Cochrane Library, MEDLINE/PubMed, Physiotherapy Evidence Database, and SciELO search (from 1985 to May 2019) for randomized controlled trials that evaluated the effects of aerobic exercise in HFpEF patients. We calculated the mean differences (MD) and 95% confidence interval (CI). Ten intervention studies were included providing a total of 399 patients. Compared with control, aerobic exercise resulted in improvement in peak VO MD 1.9 mL kg min (95% CI 1.3 to 2.5; N = 314) and HRQoL measured by Minnesota Living with Heart Failure MD 5.4 (95% CI - 10.5 to - 0.2; N = 256). No significant difference in VE/VCO slope was found between participants in the aerobic exercise group and the control group. The quality of evidence for peak VO and HRQoL was assessed as being moderate. Aerobic exercise moderately improves peak VO and HRQoL and should be considered a strategy of rehabilitation of HFpEF individuals.
本研究旨在确定有氧运动对射血分数保留心力衰竭（HFpEF）患者峰值摄氧量（peak VO）、分钟通气量/二氧化碳产量斜率（VE/VCO 斜率）和健康相关生活质量（HRQoL）的影响。
我们对 Cochrane 图书馆、MEDLINE/PubMed、物理治疗证据数据库和 SciELO 进行了检索（从 1985 年到 2019 年 5 月），以寻找评估 HFpEF 患者有氧运动效果的随机对照试验。我们计算了平均差异（MD）和 95%置信区间（CI）。纳入了 10 项干预研究，共纳入 399 名患者。与对照组相比，有氧运动使 peak VO 的 MD 增加了 1.9 mL·kg·min（95%CI 1.3 至 2.5；N=314），并且 HRQoL 也得到了改善，用明尼苏达心力衰竭生活质量问卷（Minnesota Living with Heart Failure）评估 MD 为 5.4（95%CI -10.5 至 -0.2；N=256）。在有氧运动组和对照组之间，VE/VCO 斜率没有显著差异。对 peak VO 和 HRQoL 的证据质量评估为中等。有氧运动适度改善了 peak VO 和 HRQoL，应被视为 HFpEF 患者康复的策略。
