Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Inflammopharmacology. 2020 Apr;28(2):345-362. doi: 10.1007/s10787-019-00663-9. Epub 2019 Nov 9.
Inflammation has a central role in the etiology of type 2 diabetes (T2D) and its complications. Both genetic and epigenetic factors have been implicated in the development of T2D-associated inflammation. Epigenetic mechanisms regulate the function of several components of the immune system. Diabetic conditions trigger aberrant epigenetic alterations that contribute to the progression of insulin resistance and β-cell dysfunction by induction of inflammatory responses. Thus, targeting epigenetic factors and modifications, as one of the underlying causes of inflammation, could lead to the development of novel immune-based strategies for the treatment of T2D. The aim of this review is to provide an overview of the epigenetic mechanisms involved in the propagation and perpetuation of chronic inflammation in T2D. We also discuss the possible anti-inflammatory approaches that target epigenetic factors for the treatment of T2D.
炎症在 2 型糖尿病（T2D）及其并发症的发病机制中起着核心作用。遗传和表观遗传因素都与 T2D 相关炎症的发展有关。表观遗传机制调节免疫系统的几个成分的功能。糖尿病状态引发异常的表观遗传改变，通过诱导炎症反应，导致胰岛素抵抗和β细胞功能障碍的进展。因此，针对作为炎症潜在原因之一的表观遗传因素和修饰，可以为 T2D 的治疗开发新的基于免疫的策略。本综述的目的是提供参与 T2D 中慢性炎症传播和持续的表观遗传机制的概述。我们还讨论了针对表观遗传因素治疗 T2D 的可能的抗炎方法。
