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葡萄糖-6-磷酸脱氢酶缺乏儿童可能因食用蓝莓导致溶血:一例报告

Probable blueberry-induced haemolysis in a G6PD deficient child: A case report.

作者信息

Babu Tirin, Panachiyil George Mathew, Sebastian Juny, Ravi Mandyam Dhati

机构信息

Department of Clinical Pharmacy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, Karnataka, India.

Department of Paediatrics, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysore, Karnataka, India.

出版信息

Nutr Health. 2019 Dec;25(4):303-305. doi: 10.1177/0260106019885290. Epub 2019 Nov 11.

Abstract

BACKGROUND

Blueberry is a North American native fruit increasingly popular as a source of health-promoting bioactive compounds. However, there is evidence in the literature stating that blueberries should be avoided in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

CASE PRESENTATION

We report the first case of a G6PD deficient child who developed haemolysis approximately after half a day following the intake of fresh blueberry. He presented with the complaints of the passage of orange coloured urine and hurried breathing. The child had haemoglobin of 7.9 g/dl on admission day and the laboratory results were indicative of haemolytic process.

OUTCOMES AND IMPLICATIONS

During the stay in the hospital, the child was managed conventionally, and he improved both clinically and symptomatically. The child was discharged after four days of treatment and diet counselling was provided to his parents.

RECOMMENDATIONS

Our report should encourage further research on this fruit regarding the mechanism behind the development of haemolytic anaemia. Also, it is important in the case of G6PD deficient patients to take lifelong precautions to avoid the foods that can trigger haemolysis.

摘要

背景

蓝莓是一种原产于北美的水果,作为促进健康的生物活性化合物来源,越来越受欢迎。然而,文献中有证据表明,葡萄糖-6-磷酸脱氢酶(G6PD)缺乏的个体应避免食用蓝莓。

病例报告

我们报告了第一例G6PD缺乏的儿童,在摄入新鲜蓝莓后约半天出现溶血。他表现为橙色尿液和呼吸急促。入院当天患儿血红蛋白为7.9 g/dl,实验室检查结果提示溶血过程。

结果与意义

住院期间,患儿接受了常规治疗,临床和症状均有改善。治疗四天后患儿出院,并为其父母提供了饮食咨询。

建议

我们的报告应鼓励对这种水果导致溶血性贫血的机制进行进一步研究。此外,对于G6PD缺乏的患者,终身采取预防措施以避免食用可引发溶血的食物非常重要。

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