Instituto de Investigación Biomédica de Málaga-IBIMA, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Spain.
Instituto de Investigación Biomédica de Málaga-IBIMA, Spain; Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Facultad de Psicología, Universidad de Málaga, Spain.
Curr Opin Pharmacol. 2020 Feb;50:109-116. doi: 10.1016/j.coph.2019.10.002. Epub 2019 Nov 8.
Basic research in rodents has shown that adult hippocampal neurogenesis (AHN) plays a key role in neuropsychiatric disorders that compromise hippocampal functioning. The discovery that dependence-inducing drugs regulate AHN has led to escalating interest in the potential involvement of AHN in drug addiction over the last decade, with cocaine being one of the most frequently investigated drugs. This review argues that, unlike other drugs of abuse, preclinical studies do not, overall, support that cocaine induces a marked or persistent impairment in AHN. Nevertheless, experimental reduction of AHN consistently exacerbates vulnerability to cocaine. Interestingly, preliminary evidence suggests that, on the contrary, increasing AHN might help both to prevent and treat addiction.
啮齿动物的基础研究表明，成年海马神经发生（AHN）在损害海马功能的神经精神疾病中起着关键作用。依赖诱导药物调节 AHN 的发现导致了过去十年中对 AHN 可能参与药物成瘾的兴趣日益增加，其中可卡因是研究最多的药物之一。这篇综述认为，与其他滥用药物不同，临床前研究总体上并不支持可卡因会导致 AHN 明显或持久的损伤。然而，实验性降低 AHN 会一致增加对可卡因的易感性。有趣的是，初步证据表明，相反，增加 AHN 可能有助于预防和治疗成瘾。
