淋巴细胞与单核细胞比值降低是脑静脉窦血栓形成患者预后不良的潜在预测指标。
Lower lymphocyte to monocyte ratio is a potential predictor of poor outcome in patients with cerebral venous sinus thrombosis.
机构信息
Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Cardio-Neurology Clinic and Clinical Proteomics Research Center and Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Stroke Vasc Neurol. 2018 Dec 4;4(3):148-153. doi: 10.1136/svn-2018-000180. eCollection 2019 Sep.
BACKGROUND
Lymphocyte to monocyte ratio (LMR) is associated with functional outcome in patients with stroke. But the relationship between the LMR value and the prognosis of cerebral venous sinus thrombosis (CVST) has not been investigated.
METHODS
CVST patients, admitted to the First Affiliated Hospital of Zhengzhou University, were retrospectively identified from November 2010 to January 2017. Functional outcomes of patients were evaluated with the modified Rankin Scale (mRS). Patients were divided into good (mRS 0-2) and poor (mRS 3-6) outcomes groups. Univariate and multivariate Cox regression analyses were used to assess the relationship between LMR and the poor survival outcome.
RESULTS
A total of 228 patients were included of which 41 had poor outcomes (18.0%). The duration of follow-up was 22 months (6-66 months). LMR (2.3±1.2 vs 3.2±1.8, p<0.01) was significantly lower in the poor outcome group. Multivariate Cox regression analysis showed that LMR (HR 0.726, 95% CI 0.546 to 0.964, p=0.027) was a independent predictor of poor prognosis.
CONCLUSIONS
LMR may be a predictor of poor prognosis in CVST patients.
背景
淋巴细胞与单核细胞比值（LMR）与中风患者的功能预后相关。但是，LMR 值与脑静脉窦血栓形成（CVST）的预后之间的关系尚未得到研究。
方法
本研究回顾性分析了 2010 年 11 月至 2017 年 1 月期间在郑州大学第一附属医院住院的 CVST 患者。采用改良 Rankin 量表（mRS）评估患者的功能结局。将患者分为预后良好（mRS0-2）和预后不良（mRS3-6）两组。采用单因素和多因素 Cox 回归分析评估 LMR 与不良生存结局之间的关系。
结果
共纳入 228 例患者，其中 41 例预后不良（18.0%）。随访时间为 22 个月（6-66 个月）。预后不良组的 LMR（2.3±1.2 比 3.2±1.8，p<0.01）明显较低。多因素 Cox 回归分析表明，LMR（HR0.726，95%CI0.546 至 0.964，p=0.027）是预后不良的独立预测因素。
结论
LMR 可能是 CVST 患者不良预后的预测指标。
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