Fuchs Christine S K, Ardigo Marco, Haedersdal Merete, Mogensen Mette
Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, DK-2200, Denmark.
Clinical Dermatology Department, San Gallicano Dermatological Institute-IRCCS, Rome, 00144, Italy.
Lasers Surg Med. 2020 Jan;52(1):13-16. doi: 10.1002/lsm.23179. Epub 2019 Nov 10.
Cutaneous chrysiasis is gold deposition in the dermis, described after parenteral administration of gold salts or after topical exposure to gold-containing materials. Gold microparticles (GMPs) have versatile therapeutic effects and are increasingly used in medicine. This case report describes the development of a blue-gray macule following the facial application of GMPs and laser treatment of acne vulgaris. Dermoscopy showed a nonspecific homogenous blue-gray pattern, gradually fading over an 8-month-period. Reflectance confocal microscopy (RCM) detected hyperreflective, subcellular particles in the papillary dermis, localized around hair follicles, eccrine glands, and inside macrophages. Histopathological evaluation, darkfield illumination with hyperspectral imaging, and neutron activation analysis confirmed the presence of GMPs in the dermis. RCM allowed non-invasive fast visualization of aggregates of hyperreflective particles in the dermis and can potentially be used for monitoring localized cutaneous chrysiasis and other metal deposition conditions over time. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.
皮肤金沉着症是真皮内的金沉积，在肠胃外给予金盐后或局部接触含金材料后出现。金微粒（GMPs）具有多种治疗作用，在医学中的应用越来越广泛。本病例报告描述了在面部应用金微粒和激光治疗寻常痤疮后出现蓝灰色斑的情况。皮肤镜检查显示为非特异性均匀蓝灰色图案，在8个月期间逐渐消退。反射式共聚焦显微镜（RCM）检测到乳头真皮内有高反射性亚细胞颗粒，位于毛囊、汗腺周围以及巨噬细胞内。组织病理学评估、超光谱成像暗视野照明和中子活化分析证实真皮中存在金微粒。RCM能够对真皮内高反射性颗粒聚集体进行无创快速成像，并且有可能用于长期监测局限性皮肤金沉着症和其他金属沉积情况。《激光外科学与医学》。© 2019威利期刊公司。
