Wu Xia, Yuan Bin, Huang Leitao, Yin Xiujie, Liu JiChun
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Department of Orthopedics, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
J Int Med Res. 2020 Mar;48(3):300060519885269. doi: 10.1177/0300060519885269. Epub 2019 Nov 10.
Alveolar adenoma is an isolated, well-defined peripheral lung tumor that originates from type II alveolar cells. The tumor consists of a network of simple, low-cubic, epithelium-coated lacunae with varying amounts of fine and inconspicuous-to-thick spindle cells that sometimes contain mucus sample matrix. Few cases of alveolar adenoma have been reported. These tumors are usually detected by imaging examinations where the alveolar adenoma typically presents as a peripheral, solitary cystic nodule in the lung. The presentation may mimic that of other types of lung tumors, consequently leading to difficulties in the differential diagnosis of this condition. Thus, accurate diagnosis of alveolar adenoma is based on a combination of pathological sections and immunohistochemistry. This study describes an alveolar adenoma in a 59-year-old female patient. Chest X-ray imaging and chest computed tomography identified malignant lesions in the right upper lobe. The patient subsequently underwent a thoracoscopic right upper lobectomy. The diagnosis of alveolar adenoma was confirmed after pathological examination of the excised postoperative tissue. The disease course was stable, and there was no recurrence of pulmonary lesions during 3 years of postoperative patient follow-up. Herein, we report the case of a patient with benign alveolar adenoma with poor imaging and pathological results.
肺泡腺瘤是一种孤立的、边界清晰的周围型肺肿瘤，起源于II型肺泡细胞。肿瘤由简单的、低立方的、上皮覆盖的腔隙网络组成，伴有数量不等的纤细且不明显至粗大的梭形细胞，这些细胞有时含有黏液样基质。肺泡腺瘤的病例报道较少。这些肿瘤通常通过影像学检查发现，肺泡腺瘤在影像学上通常表现为肺部的外周孤立性囊性结节。其表现可能与其他类型的肺肿瘤相似，因此导致该疾病的鉴别诊断存在困难。因此，肺泡腺瘤的准确诊断基于病理切片和免疫组化的结合。本研究描述了一名59岁女性患者的肺泡腺瘤。胸部X线成像和胸部计算机断层扫描发现右上叶有恶性病变。患者随后接受了胸腔镜右上叶切除术。对切除的术后组织进行病理检查后确诊为肺泡腺瘤。病程稳定，术后3年患者随访期间肺部病变无复发。在此，我们报告一例影像学和病理结果不佳的良性肺泡腺瘤患者的病例。
