School of Medical Sciences, Örebro University, Örebro, Sweden.
Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Psychother Res. 2020 Nov;30(8):1011-1025. doi: 10.1080/10503307.2019.1686190. Epub 2019 Nov 10.
In this study, we evaluate the efficacy of outpatient individual cognitive behavioral therapy for young adults (CBT-YA) and combined family/individual therapy for young adults (FT-YA) for anorexia nervosa (AN). Participants (aged 17-24 years) with AN in Sweden were recruited and assigned to 18 months of CBT-YA or FT-YA. Treatment efficacy was assessed primarily using BMI, presence of diagnosis, and degree of eating-related psychopathology at post-treatment and follow-up. Secondary outcomes included depression and general psychological psychopathology. The trial was registered at http://www.isrctn.com/, ISRCTN (25181390). Seventy-eight participants were randomized, and seventy-four of them received allocated treatment and provided complete data. Clinical outcomes from within groups resulted in significant improvements for both groups. BMI increased from baseline (CBT-YA 16.49; FT-YA 16.54) to post-treatment (CBT-YA 19.61; FT-YA 19.33) with high effect sizes. The rate of weight restoration was 64.9% in the CBT-YA group and 83.8% in the FT-YA group. The rate of recovery was 76% in both groups at post-treatment, and at follow-up, 89% and 81% had recovered in the CBT-YA and FT-YA groups respectively. Outpatient CBT-YA and FT-YA appear to be of benefit to young adults with AN in terms of weight restoration and reduced eating disorder and general psychopathology.
在这项研究中，我们评估了门诊个体认知行为疗法（CBT-YA）和联合家庭/个体疗法（FT-YA）对青少年神经性厌食症（AN）的疗效。在瑞典招募了患有 AN 的青少年（年龄在 17-24 岁之间），并将他们分配到 18 个月的 CBT-YA 或 FT-YA 治疗中。治疗效果主要通过 BMI、诊断存在情况和治疗后及随访时进食相关心理病理学的严重程度来评估。次要结果包括抑郁和一般心理病理学。该试验在 http://www.isrctn.com/ 上注册，ISRCTN（25181390）。共有 78 名参与者被随机分配，其中 74 名接受了分配的治疗并提供了完整的数据。组内临床结果显示两组均有显著改善。BMI 从基线（CBT-YA 为 16.49；FT-YA 为 16.54）增加到治疗后（CBT-YA 为 19.61；FT-YA 为 19.33），具有高效应量。CBT-YA 组体重恢复率为 64.9%，FT-YA 组为 83.8%。治疗后两组的恢复率均为 76%，随访时 CBT-YA 组和 FT-YA 组分别有 89%和 81%的人恢复。门诊 CBT-YA 和 FT-YA 似乎对 AN 青少年的体重恢复和减少进食障碍和一般心理病理学都有益。
