Šinkorová Zuzana, Filipová Alžběta, Vávrová Jiřina, Pejchal Jaroslav, Andrejsová Lenka, Jeličová Marcela, Marek Jan, Havelek Radim, Seifrtová Martina, Řezáčová Martina, Tichý Aleš
Department of Radiobiology, University of Defence, 500 01 Hradec Kralove, Czech Republic.
Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic.
Radiat Prot Dosimetry. 2019 Dec 31;186(2-3):149-154. doi: 10.1093/rpd/ncz192.
The increasing risk of acute large-scale exposure of ionising irradiation on the population underlines the necessity of developing effective radioprotective and mitigating agents. The aim of this work was to investigate the effect of sodium orthovanadate pre-treatment on mice exposed to high doses of gamma rays (from 5 to 13 Gy). The determination of median lethal dose within 30 days confirmed that orthovanadate applied to total-body-irradiated mice intra-peritoneally has a radioprotective but not a mitigating effect. With orthovanadate pre-treatment, the composition of cellularity in the bone marrow improved substantially and the main lymphocyte populations restored during the first month after irradiation. These findings contribute to 'gap-filling' in radioprotective effects and demonstrate the importance of haematological parameters in radiation-response prediction.
人群遭受急性大规模电离辐射的风险不断增加，这凸显了开发有效辐射防护和缓解剂的必要性。本研究的目的是探讨原钒酸钠预处理对暴露于高剂量γ射线（5至13 Gy）的小鼠的影响。30天内中位致死剂量的测定证实，腹腔注射原钒酸钠对全身照射的小鼠具有辐射防护作用，但没有缓解作用。通过原钒酸钠预处理，骨髓细胞组成在照射后的第一个月内得到显著改善，主要淋巴细胞群体得以恢复。这些发现有助于填补辐射防护效应方面的“空白”，并证明血液学参数在辐射反应预测中的重要性。
