Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus, Denmark.
Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43- 45, DK-8200, Aarhus, Denmark; Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), 650 Charles E. Young Drive South, Los Angeles, CA, 90095-1772, USA.
Reprod Toxicol. 2020 Jan;91:35-42. doi: 10.1016/j.reprotox.2019.11.003. Epub 2019 Nov 8.
We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95 % confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.
我们探讨了母亲在妊娠早期的饮酒量是否与子女的青春期发育时间有关。共有 15819 名儿童出生于 2000 年至 2003 年，参加了丹麦全国出生队列研究，他们在 2012 年至 2018 年期间的 11 年中，每半年报告一次青春期发育（Tanner 分期、变声、首次射精、初潮、痤疮和腋毛）的情况。母亲在怀孕期间自我报告了妊娠早期的平均饮酒量和 binge drinking 情况（同一时间饮酒量≥5 杯）。妊娠早期每周平均饮酒量≥5 杯与儿子的青春期发育时间无关（以不饮酒为参照）。当将所有青春期发育里程碑的估计值结合起来时，女儿的青春期发育时间有提前的趋势（-2.0（95%置信区间：-4.2，0.3）个月）。妊娠早期 binge drinking 与儿子和女儿的青春期发育时间均无关。
