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[First-line sedation with dexmedetomidine-end of the story?].

作者信息

Weiss Björn

机构信息

Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland.

出版信息

Med Klin Intensivmed Notfmed. 2020 Apr;115(3):260-262. doi: 10.1007/s00063-019-00627-5.

DOI:10.1007/s00063-019-00627-5
PMID:31712833
Abstract
摘要

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本文引用的文献

1
What Is Safe Sedation in the ICU?重症监护病房中的安全镇静是什么?
N Engl J Med. 2019 Jun 27;380(26):2577-2578. doi: 10.1056/NEJMe1906522.
2
Early Sedation with Dexmedetomidine in Critically Ill Patients.重症患者的右美托咪定早期镇静。
N Engl J Med. 2019 Jun 27;380(26):2506-2517. doi: 10.1056/NEJMoa1904710. Epub 2019 May 19.
3
Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial.右美托咪定联合标准治疗对躁动谵妄患者呼吸机使用时间的影响:一项随机临床试验。
JAMA. 2016 Apr 12;315(14):1460-8. doi: 10.1001/jama.2016.2707.
4
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.右美托咪定对比咪达唑仑或丙泊酚用于机械通气时间延长患者的镇静:两项随机对照试验
JAMA. 2012 Mar 21;307(11):1151-60. doi: 10.1001/jama.2012.304.
5
A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial.无镇静方案用于接受机械通气的危重症患者的研究方案:一项随机试验。
Lancet. 2010 Feb 6;375(9713):475-80. doi: 10.1016/S0140-6736(09)62072-9. Epub 2010 Jan 29.
6
Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.右美托咪定与劳拉西泮镇静对机械通气患者急性脑功能障碍的影响:MENDS随机对照试验
JAMA. 2007 Dec 12;298(22):2644-53. doi: 10.1001/jama.298.22.2644.
7
Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat.反义技术表明,α2A肾上腺素能受体是介导大鼠蓝斑对高选择性激动剂右美托咪定产生催眠反应的亚型。
J Clin Invest. 1996 Sep 1;98(5):1076-80. doi: 10.1172/JCI118887.