抗核因子延迟出现与肾小球肾炎中系统性红斑狼疮的诊断
The delayed appearance of an antinuclear factor and the diagnosis of systemic lupus erythematosus in glomerulonephritis.
作者信息
Cairns S A, Acheson E J, Corbett C L, Dosa S, Mallick N P, Lawler W, Williams G
出版信息
Postgrad Med J. 1979 Oct;55(648):723-7. doi: 10.1136/pgmj.55.648.723.
Abstract
In 11 patients who presented with apparently idiopathic glomerular disease the antinuclear factor (ANF) was absent initially but was eventually detected during observation extending over 6 years. In 4 patients a diagnosis of systemic lupus erythematosus (SLE) has now been made and the disease treated. Of the remaining 7, 2 had conditions known to be associated with a positive ANF, and in 4, drug therapy induced the ANF. Clinical features, complement studies and measurement of anti-DNA antibody were of value in distinguishing those patients with SLE from the others.
摘要
11例表现为明显特发性肾小球疾病的患者，最初抗核因子（ANF）阴性，但在长达6年的观察期内最终检测到阳性。其中4例现已诊断为系统性红斑狼疮（SLE）并接受治疗。其余7例中，2例患有已知与ANF阳性相关的疾病，4例因药物治疗导致ANF阳性。临床特征、补体研究及抗DNA抗体检测对于区分SLE患者与其他患者具有重要价值。
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The delayed appearance of an antinuclear factor and the diagnosis of systemic lupus erythematosus in glomerulonephritis.抗核因子延迟出现与肾小球肾炎中系统性红斑狼疮的诊断
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