Froelich J W, Strauss H W, Moore R H, McKusick K A
Division of Magnetic Resonance Imaging, Massachusetts General Hospital, Boston 02114.
J Nucl Med. 1988 Oct;29(10):1714-8.
Exercise induced changes in the blood volume of visceral organs (cardiopulmonary and liver, spleen, and kidneys) were determined by scintillation camera imaging of the distribution of technetium-99m-labeled red blood cells in the thorax and abdomen of ten healthy adult volunteers. Graded upright bicycle exercise was performed to the point of exhaustion with the volunteer positioned with his/her back to the scintillation camera and data recording was synchronized to the pedal cycle to minimize patient motion artifacts within the data. The first image from each level of exercise was analyzed by placing regions of interest over the spleen, liver, kidneys, and right lung. The counts in each organ were expressed as a percent of activity at zero workload. Analysis of data using Hotelling's t-squared analysis to see if overall differences existed between the last four measurements (up to the time of exhaustion) regarding percent change from baseline for spleen, kidney, liver, and right lung were made. The splanchnic bed had a significant decrease in blood volume. The spleen decreased 39%, while the liver decreased 14%. For the kidney and liver, no significant differences were achieved (p greater than 0.24, p less than 0.15, respectively). The lung increased its blood volume to 128% of control, significant with p less than 0.02. This data demonstrates that in healthy volunteers there is normal redistribution of blood volume during maximal exercise with a significant reduction in blood volume of the spleen as well as a significant rise in blood volume within the lungs.
通过对10名健康成年志愿者胸部和腹部99m锝标记红细胞分布的闪烁相机成像，确定运动引起的内脏器官（心肺、肝脏、脾脏和肾脏）血容量变化。让志愿者背向闪烁相机进行分级直立自行车运动直至疲劳，数据记录与踏板周期同步，以尽量减少数据中的患者运动伪影。对每个运动水平的第一张图像进行分析，在脾脏、肝脏、肾脏和右肺上放置感兴趣区域。每个器官的计数表示为零工作量时活性的百分比。使用霍特林T平方分析对数据进行分析，以查看在最后四次测量（直至疲劳时）中，脾脏、肾脏、肝脏和右肺相对于基线的百分比变化是否存在总体差异。内脏床血容量显著下降。脾脏下降39%，而肝脏下降14%。肾脏和肝脏未观察到显著差异（分别为p大于0.24，p小于0.15）。肺的血容量增加到对照的128%，p小于0.02，差异显著。该数据表明，在健康志愿者中，最大运动期间血容量正常重新分布，脾脏血容量显著减少，肺内血容量显著增加。
