Bhatt Priyanka, Kelly Shannon, Sutariya Vijaykumar
Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, 12901 Bruce B Downs Blvd, MDC 30, Tampa, FL 33612-4749, USA.
Ther Deliv. 2019 Nov;10(11):737-747. doi: 10.4155/tde-2019-0025. Epub 2019 Nov 13.
Pathologic posterior neovascularization of eye is a major cause of irreversible vision loss and limitations of therapeutics to be successfully delivered to back of the eye has been a main obstacle for its effective treatment. Current pharmacological treatment using anti-VEGF agents being delivered intravitreally are effective but complicated due to anatomical and physiological barriers, as well as administration of high and frequent doses. With expanding horizons of nanotechnology, it can be possible to formulate promising nanoscale delivery system to improve penetration and sustained the release of therapeutic in posterior segment of the eye. Taking into consideration advances in the field of nanoscale delivery systems, this special report focuses on emerging strategies and their applications for treatment of posterior ocular neovascularization.
眼部病理性新生血管形成是不可逆视力丧失的主要原因，而将治疗药物成功递送至眼后段的限制一直是其有效治疗的主要障碍。目前通过玻璃体内注射抗血管内皮生长因子（VEGF）药物进行的药物治疗虽有效，但由于解剖学和生理学屏障以及高剂量和频繁给药，治疗过程较为复杂。随着纳米技术的不断发展，有可能开发出有前景的纳米级递送系统，以提高药物在眼后段的渗透和持续释放。考虑到纳米级递送系统领域的进展，本专题报告重点关注治疗眼后段新生血管形成的新兴策略及其应用。
