Karahan Mine, Hazar Leyla, Erdem Seyfettin, Ava Sedat, Dursun Mehmet Emin, Demirtaş Atılım Armağan, Keklikçi Uğur
Department of Ophthalmology, School of Medicine, Dicle University, Diyarbakır, Turkey.
Assistant Professor, Department of Ophthalmology, School of Medicine, Dicle University, Sur, Diyarbakır 21280, Turkey.
Ther Adv Ophthalmol. 2021 Apr 27;13:25158414211010550. doi: 10.1177/25158414211010550. eCollection 2021 Jan-Dec.
We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD).
In this retrospective study, patients were divided into three groups: wet-type AMD ( = 60), dry-type AMD ( = 60), and healthy controls ( = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually.
The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group ( < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group ( < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group ( = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively.
Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.
我们旨在分析年龄相关性黄斑变性（AMD）患者的血液炎症参数。
在这项回顾性研究中，患者被分为三组：湿性AMD组（n = 60）、干性AMD组（n = 60）和健康对照组（n = 71）。分析患者的实验室和人口统计学数据。手动计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和单核细胞与淋巴细胞比值（MLR）。
干性AMD组的平均NLR为2.26±1.42，湿性AMD组为3.90±1.65，对照组为1.84±0.61（P < 0.001）。干性AMD组的平均MLR为0.30±0.20，湿性AMD组为0.47±0.31，对照组为0.28±0.14（P < 0.001）。干性AMD组的平均PLR为129.31±79.82，湿性AMD组为156.67±83.99，对照组为135.59±58.68（P = 0.101）。受试者工作特征（ROC）曲线分析显示，湿性AMD的NLR和MLR曲线下面积（AUC）分别为0.920和0.717。湿性AMD的NLR敏感性和特异性分别为64%和93%，而MLR分别为63%和75%。
简单的血液检测显示，湿性AMD患者的NLR和MLR显著高于干性AMD患者和健康对照组，这意味着存在低度炎症。
