Attalla Mark G, Singh Sangeeta B, Khalid Raheela, Umair Musab, Epenge Emmanuel
Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Urology, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Cureus. 2019 Sep 18;11(9):e5695. doi: 10.7759/cureus.5695.
Ulcerative colitis (UC) is a colonic disease characterized by chronic inflammation. Rheumatoid arthritis (RA) is a rheumatological chronic inflammatory disease characterized by joint swelling and tenderness. It is also considered an autoimmune disorder. We want to discover if a link exists between UC and RA and if so, how UC affects the progress of arthritis. We used PRISMA guidelines. In this study, we used PubMed, PubMed Central (PMC), and Google Scholar to collect data. Studies conducted more than 50 years ago, non-English articles, and animal studies were excluded. All types of studies were included. We used keywords like "ulcerative colitis", "rheumatoid arthritis", or "colitic arthritis" in the search. We identified the following sets of results: 187,611 PubMed studies, 197,610 PMC studies, and 2,282,000 Google scholar studies. After applying inclusion and exclusion criteria, the number of appropriate studies was narrowed down to 50. Arthritis is the most common complication of ulcerative UC. The radiological changes are similar to those seen in RA. There are common genes and antigens found in both diseases, such as human leukocyte antigen (HLA-B27), interleukin 15, IgA. Certain drugs used for the treatment of both disorders, including omega-3. Many studies revealed that a large number of patients with UC developed RA within a few years. All the findings prove that there is a relation between ulcerative colitis and rheumatoid arthritis. This study is useful for doctors, scientists, and patients.
溃疡性结肠炎（UC）是一种以慢性炎症为特征的结肠疾病。类风湿性关节炎（RA）是一种以关节肿胀和压痛为特征的风湿性慢性炎症性疾病。它也被认为是一种自身免疫性疾病。我们想探究UC和RA之间是否存在联系，如果存在，UC如何影响关节炎的进展。我们采用了PRISMA指南。在本研究中，我们使用PubMed、PubMed Central（PMC）和谷歌学术来收集数据。排除50多年前进行的研究、非英文文章和动物研究。纳入所有类型的研究。我们在搜索中使用了“溃疡性结肠炎”、“类风湿性关节炎”或“结肠性关节炎”等关键词。我们得到了以下几组结果：187,611篇PubMed研究、197,610篇PMC研究和2,282,000篇谷歌学术研究。应用纳入和排除标准后，合适的研究数量缩小到50项。关节炎是溃疡性UC最常见的并发症。放射学改变与RA所见相似。两种疾病中发现了共同的基因和抗原，如人类白细胞抗原（HLA - B27）、白细胞介素15、免疫球蛋白A。用于治疗这两种疾病的某些药物，包括ω-3。许多研究表明，大量UC患者在几年内发展为RA。所有这些发现证明溃疡性结肠炎和类风湿性关节炎之间存在关联。这项研究对医生、科学家和患者都有用。
