Shandong University of Traditional Chinese Medicine, Shandong, China.
Comput Math Methods Med. 2022 Jul 11;2022:5927384. doi: 10.1155/2022/5927384. eCollection 2022.
Ulcerative colitis (UC) is a kind of inflammatory bowel disease which is needed to be predicted.
To analyze various animal models of UC conditions and summarizes the animal selection, model progression, and pathogenic mechanisms of UC animal models.
We surveyed the research papers published in PubMed, Google Scholar, Baidu Scholar, CNKI, SciFinder, and Web of Science in the past 5 years and discussed the experimental animals, modeling methods, and pathogenic mechanisms.
In the selection of experimental animals, rats are considered the best experimental animals. The mainstream modeling methods can be categorized into the chemical stimulation method, immune stimulation method, and compound method, among which the compound method is the most successful. In the study of the pathogenesis of UC, the pathogenesis of UC is due to various pathogenic factors, such as nitric oxide (NO), prostaglandins (PG), proinflammatory factors (IL, TNF-), and intestinal flora.
The method of building an animal model of UC is well-established, providing a more targeted selection of animal models for future related experiments.
溃疡性结肠炎（UC）是一种炎症性肠病，需要进行预测。
分析各种 UC 动物模型的情况，并总结 UC 动物模型的动物选择、模型进展和发病机制。
我们调查了过去 5 年在 PubMed、Google Scholar、百度学术、CNKI、SciFinder 和 Web of Science 上发表的研究论文，并讨论了实验动物、建模方法和发病机制。
在实验动物的选择中，大鼠被认为是最佳的实验动物。主流的建模方法可分为化学刺激法、免疫刺激法和复合法，其中复合法最成功。在 UC 发病机制的研究中，UC 的发病机制是由于各种致病因素，如一氧化氮（NO）、前列腺素（PG）、促炎因子（IL、TNF-）和肠道菌群。
UC 动物模型的构建方法已经成熟，为未来相关实验提供了更有针对性的动物模型选择。
