Department of Cell Biology, Regeneration Next, Duke University Medical Center, Durham, North Carolina.
Department of Clinical Science, University of Bergen, Bergen, Norway.
Stem Cells. 2020 Mar;38(3):330-339. doi: 10.1002/stem.3118. Epub 2019 Nov 28.
To date, most attention on tissue regeneration has focused on the exploration of positive cues promoting or allowing the engagement of natural cellular restoration upon injury. In contrast, the signals fostering cell identity maintenance in the vertebrate body have been poorly investigated; yet they are crucial, for their counteraction could become a powerful method to induce and modulate regeneration. Here we review the mechanisms inhibiting pro-regenerative spontaneous adaptive cell responses in different model organisms and organs. The pharmacological or genetic/epigenetic modulation of such regenerative brakes could release a dormant but innate adaptive competence of certain cell types and therefore boost tissue regeneration in different situations.
迄今为止，大多数组织再生研究都集中在探索促进或允许受伤后细胞自然修复的正向信号上。相比之下，对于维持脊椎动物体内细胞特性的信号的研究还很少；但这些信号至关重要，因为抑制它们可能成为一种强大的方法，以诱导和调节再生。在这里，我们综述了不同模式生物和器官中抑制促再生自发适应性细胞反应的机制。通过药理学或遗传学/表观遗传学手段调节这些再生刹车，可以释放某些细胞类型的休眠但固有适应性能力，从而在不同情况下促进组织再生。
