Pressure lowering effect of timolol with reference to its topical vascular action.

The hemodynamic effect of timolol maleate in open angle glaucoma was studied rheo-oculographically. Increase in the ocular pulse which reaches maximal amplification 2 h after the instillation of the drug was observed. The maximal pressure lowering effect appeared 3 h after instillation, as if the hemodynamic effect were the trigger for the pressure lowering effect.