早期F-18 Florapronal PET与F-18 FDG PET在阿尔茨海默病和正常大脑中的相关性
Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer's Disease and Normal Brain.
作者信息
Jeong Jieun, Jeong Young Jin, Park Kyung Won, Kang Do-Young
机构信息
1Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan, 602-715 South Korea.
2Institute of Convergence Bio-Health, Dong-A University, Busan, South Korea.
出版信息
Nucl Med Mol Imaging. 2019 Oct;53(5):328-333. doi: 10.1007/s13139-019-00612-y. Epub 2019 Sep 11.
PURPOSE
F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer's dementia (AD) patients.
METHODS
A total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson's correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated.
RESULTS
We compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions.
CONCLUSIONS
Early F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.
目的
F-18 florapronol（FPN）是韩国商业认可的β-淀粉样蛋白正电子发射断层扫描（PET）放射性示踪剂。本研究比较了健康对照（HC）和阿尔茨海默病（AD）患者早期F-18 florapronol PET与F-18氟脱氧葡萄糖（FDG）PET的情况。
方法
共有29名受试者（15名HC和14名AD受试者）接受了F-18 FPN PET和F-18 FDG PET检查。F-18 FDG PET图像在30至60分钟采集，F-18 FPN PET在0至10分钟采集。F-18 FPN和F-18 FDG图像使用从个体CT图像获得的变换矩阵进行空间归一化，并从小脑区域计算标准化摄取值比值（SUVR），使用PMOD 3.6计算全局平均值。计算预定义皮质脑区F-18 FDG与早期F-18 FPN之间的Pearson相关系数。
结果
我们在全局平均值归一化和小脑归一化中比较了特定区域SUVR的F-18 FDG和F-18 FPN，全局平均值归一化中的大多数相关系数更高。在全局平均值归一化中，所有脑区HC的SUVR相关系数均高于AD。
结论
早期F-18 FPN研究可作为F-18 FDG PET的替代标志物。
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