使用F-18氟贝他宾PET对认知正常的韩国成年人进行脑淀粉样蛋白定量分析。
Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET.
作者信息
Jeong Jieun, Jeong Young Jin, Park Kyung Won, Kang Do-Young
机构信息
1Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan, 602-715 South Korea.
2Institute of Convergence Bio-Health, Dong-A University, Busan, South Korea.
出版信息
Nucl Med Mol Imaging. 2019 Oct;53(5):334-339. doi: 10.1007/s13139-019-00609-7. Epub 2019 Aug 28.
PURPOSE
To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).
METHODS
We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50-70 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.
RESULTS
The distribution of amyloid beta for each brain region revealed no age-related trends ( > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25).
CONCLUSIONS
We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer's disease.
目的
使用F-18氟贝他宾（FBB）研究认知正常的韩国成年人脑区β淀粉样蛋白的潴留情况。
方法
我们采用自动定量分析方法，对30名认知健康的成年人（年龄范围50 - 70岁）的F-18 FBB正电子发射断层扫描（PET）/CT图像进行了前瞻性分析。通过将各区域计数与小脑皮质进行归一化处理，计算出F-18 FBB在预定义区域的标准化摄取值比率（SUVRs）。
结果
每个脑区β淀粉样蛋白的分布未显示出与年龄相关的趋势（P>0.05）。在所有受试者中，淀粉样蛋白沉积的平均SUVR为1.30±0.18。右侧顶叶的SUVR值最高（1.46±0.23），而右侧额叶和左侧楔前叶的SUVR最低（1.23±0.25）。
结论
我们提供了从健康韩国老年人中获得的规范数据的参考值，并建议将其用于阿尔茨海默病患者的准确诊断。
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