使用F-氟贝他班对认知正常的老年人脑内β-淀粉样蛋白滞留情况进行全脑体素水平分析
Whole Brain Voxel-Wise Analysis of Cerebral Retention of Beta-Amyloid in Cognitively Normal Older Adults Using F-Florbetaben.
作者信息
Um Yoo Hyun, Choi Woo Hee, Jung Won Sang, Park Young Ha, Lee Chang-Uk, Lim Hyun Kook
机构信息
Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Radiology, Division of Nuclear Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
出版信息
Psychiatry Investig. 2017 Nov;14(6):883-886. doi: 10.4306/pi.2017.14.6.883. Epub 2017 Nov 7.
OBJECTIVE
Recently developed 18F-labelled amyloid beta (Aβ) positron emission tomography (PET) tracers have demonstrated potentials to enable more prevalent application of amyloid imaging in the clinical setting. The aim of this study is to demonstrate cerebral retention of Aβ in cognitively normal older adults, by implementing voxel-based analysis on images acquired from F-Florbetaben amyloid PET.
METHODS
Fifty cognitive normal elderly subjects were recruited and included in the study. Demographic data and cognitive measurements were collected. Magnetic resonance imaging (MRI) and F-Florbetaben PET data were obtained followed by whole brain voxel-based analysis.
RESULTS
Compared to the florbetaben (FBB) (-) counterpart, FBB (+) showed significantly higher Aβ deposition in the brain regions comprising anterior cingulate, middle cingulate, posterior cingulate and precuneus (family wise error corrected p<0.05). There was no significant correlation between amyloid retention and cognitive functions.
CONCLUSION
Our results confirms previous results regarding Aβ deposition by using F-Florbetaben, demonstrating potentials in application of F-Florbetaben PET imaging in clinical settings.
目的
最近开发的18F标记的淀粉样β蛋白（Aβ）正电子发射断层扫描（PET）示踪剂已显示出在临床环境中使淀粉样成像更广泛应用的潜力。本研究的目的是通过对从F-氟比他滨淀粉样PET获取的图像进行基于体素的分析，来证明认知正常的老年人脑中Aβ的滞留情况。
方法
招募了50名认知正常的老年受试者并纳入研究。收集了人口统计学数据和认知测量结果。获取了磁共振成像（MRI）和F-氟比他滨PET数据，随后进行全脑基于体素的分析。
结果
与氟比他滨（FBB）（-）组相比，FBB（+）组在前扣带回、中扣带回、后扣带回和楔前叶等脑区显示出明显更高的Aβ沉积（经家族性错误校正p<0.05）。淀粉样蛋白滞留与认知功能之间无显著相关性。
结论
我们的结果证实了之前使用F-氟比他滨关于Aβ沉积的结果，证明了F-氟比他滨PET成像在临床环境中的应用潜力。
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