Uemura Akiko, Ogawa Shingo, Isono Yasuyuki, Tanaka Ryou
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
R&D Department of Medical Field Product and Cosmetics Material, Fundamental Research Division, Dainichiseika Color & Chemicals Mfg. Co., Ltd., Tokyo, Japan.
J Tissue Eng. 2019 Nov 5;10:2041731419885032. doi: 10.1177/2041731419885032. eCollection 2019 Jan-Dec.
Degradation rate of hyaluronic acid to prolong its stability in vivo would be beneficial. We investigated a potential solution for prolonging the stability of hyaluronic acid within the body. We focused on decreasing the swelling ratio to slow the degradation rate of hyaluronic acid by insolubilizing sodium hyaluronate without using potentially harmful substances such as crosslinkers or modifiers. Hyaluronic acid formulations were created with three different swelling ratios and time-dependent morphological changes in hyaluronic acid formulations and were scored based on each swelling ratio. In vivo degradation was modeled in simulated body fluid and the extent of decay of test membranes were monitored over time. Results showed that, by adjusting the swelling ratio, the degradation rate of hyaluronic acid formulation could be controlled. Our research could lead to improvements in many products, not only preventive materials for postoperative adhesions, but also pharmaceutical products such as osteoarthritis treatments and cosmetic medicines.
降低透明质酸的降解速率以延长其在体内的稳定性将是有益的。我们研究了一种延长透明质酸在体内稳定性的潜在解决方案。我们专注于通过不使用交联剂或改性剂等潜在有害物质使透明质酸钠不溶解来降低溶胀率，从而减缓透明质酸的降解速率。制备了具有三种不同溶胀率的透明质酸制剂，并观察了透明质酸制剂随时间的形态变化，并根据每种溶胀率进行评分。在模拟体液中对体内降解进行建模，并随时间监测测试膜的衰减程度。结果表明，通过调节溶胀率，可以控制透明质酸制剂的降解速率。我们的研究可能会改进许多产品，不仅包括术后粘连的预防材料，还包括骨关节炎治疗和美容药物等药品。
