Tokyo University of Agriculture and Technology Animal Medical Center, 3-5-8 Saiwaicho, Fuchu-shi, Tokyo 183-8509, Japan.
National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.
Int J Med Sci. 2018 Apr 27;15(7):689-695. doi: 10.7150/ijms.24050. eCollection 2018.
: The need to prevent postoperative adhesions after surgery has been considered a significant challenge in thoracic surgery, especially with the advent of video-assisted thoracic surgery (VATS). While preventive materials for postoperative adhesions have been studied for many years, they are all still in the development phases. : In this animal study, an insoluble hyaluronic acid membrane was used in VATS for wedge resection to test its operability and to examine the body's response to the membrane. Ten beagles were divided into two groups, an experimental group and a negative control group. In the experimental group, an insoluble hyaluronic acid membrane containing glycerol was used as the test membrane (10 x 10 x 0.1 cm). The test membrane was implanted in the left thoracic cavity of the animal under VATS following wedge resection. The animals were observed for two weeks and then euthanized for examination. : Macroscopically, the median adhesion score was lower in the experimental group (0) than in the control group (2.5). On histopathological examination, the test membrane elicited only a minor inflammatory response and foreign body reaction. : The test membrane showed satisfactory operability and appears to be a practical material to prevent postoperative adhesions after thoracic surgery in VATS.
: 手术后预防粘连一直被认为是胸外科的一个重大挑战，尤其是在电视辅助胸腔镜手术（VATS）出现之后。尽管多年来一直在研究预防术后粘连的材料，但它们仍处于开发阶段。: 在这项动物研究中，在 VATS 下进行楔形切除时使用了不可吸收的透明质酸膜，以测试其可操作性，并检查机体对该膜的反应。10 只比格犬分为实验组和阴性对照组。在实验组中，使用含有甘油的不可吸收透明质酸膜作为测试膜（10x10x0.1cm）。在 VATS 下进行楔形切除后，将测试膜植入动物的左胸腔。观察动物两周，然后处死进行检查。: 大体观察，实验组（0）的平均粘连评分低于对照组（2.5）。组织病理学检查显示，测试膜仅引起轻微的炎症反应和异物反应。: 测试膜显示出良好的可操作性，似乎是一种实用的材料，可以预防 VATS 下胸腔手术后的粘连。
