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维甲酸诱导的逆转录病毒感染的HL-60细胞分化与病毒长末端重复序列转录增强有关。

Retinoic acid-induced differentiation of retrovirus-infected HL-60 cells is associated with enhanced transcription from the viral long terminal repeat.

作者信息

Collins S J

机构信息

Molecular Medicine Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.

出版信息

J Virol. 1988 Nov;62(11):4349-52. doi: 10.1128/JVI.62.11.4349-4352.1988.

DOI:10.1128/JVI.62.11.4349-4352.1988
PMID:3172345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253871/
Abstract

I infected different human leukemic cell lines with an amphotropic retrovirus vector (designated PA317/N2) which confers G418 resistance and contains the Moloney murine leukemia virus long terminal repeat. In retrovirus-infected G418-resistant HL-60 cells, induction of granulocyte differentiation by retinoic acid was invariably accompanied by a marked increase (5- to 10-fold) in the transcriptional activity of the integrated retroviral long terminal repeat.

摘要

我用一种兼嗜性逆转录病毒载体（命名为PA317/N2）感染了不同的人类白血病细胞系，该载体赋予细胞对G418的抗性，并含有莫洛尼鼠白血病病毒长末端重复序列。在逆转录病毒感染的对G418有抗性的HL-60细胞中，维甲酸诱导粒细胞分化总是伴随着整合的逆转录病毒长末端重复序列转录活性的显著增加（5至10倍）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/4314d8c7de6b/jvirol00090-0447-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/818519dbfd09/jvirol00090-0446-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/581db93affb6/jvirol00090-0446-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/691c4f809b9a/jvirol00090-0446-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/4314d8c7de6b/jvirol00090-0447-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/818519dbfd09/jvirol00090-0446-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/581db93affb6/jvirol00090-0446-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/691c4f809b9a/jvirol00090-0446-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78fe/253871/4314d8c7de6b/jvirol00090-0447-a.jpg

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RNA processing errors in patients with beta-thalassemia.β地中海贫血患者的RNA加工错误。
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