Henry K, Miller J, Mori M, Loening S, Fallon B
Department of Urology, University of Iowa Hospitals and Clinics, Iowa City.
J Urol. 1988 Nov;140(5):964-7. doi: 10.1016/s0022-5347(17)41899-4.
We evaluated the survival rate and time to recurrence for 114 patients in whom an initial histological diagnosis of stage B1 or B2 bladder tumor was made between 1974 and 1983. The 5-year survival rates for stages B1 and B2 disease, respectively, were 63 and 38 per cent in 43 patients treated by transurethral resection alone, 48 and 54 per cent in 40 treated by preoperative radiation and radical cystectomy, 33 and 25 per cent in 15 treated by radical cystectomy alone, and 53 and 11 per cent in 16 treated by definitive radiation therapy alone. Similar results were found among the groups with regard to time to development of metastases. The distribution of stage, grade and number of tumors was not significantly different among the treatment groups. Patients in the transurethral resection group were older, and had smaller tumors and more medical problems. Comparing transurethral resection of muscle invasive bladder tumors to standard radical surgery with or without radiotherapy yielded comparable long-term survival and time to distant recurrence.
我们评估了1974年至1983年间最初经组织学诊断为B1或B2期膀胱肿瘤的114例患者的生存率和复发时间。在仅接受经尿道切除术治疗的43例患者中，B1期和B2期疾病的5年生存率分别为63%和38%；在接受术前放疗和根治性膀胱切除术治疗的40例患者中，分别为48%和54%；在仅接受根治性膀胱切除术治疗的15例患者中，分别为33%和25%；在仅接受确定性放疗治疗的16例患者中，分别为53%和11%。在转移发生时间方面，各治疗组间结果相似。各治疗组在肿瘤分期、分级和数量分布上无显著差异。经尿道切除术组的患者年龄较大，肿瘤较小且有更多的内科问题。将肌肉浸润性膀胱肿瘤的经尿道切除术与接受或未接受放疗的标准根治性手术相比较，其长期生存率和远处复发时间相当。
