Bracken R B, McDonald M W, Johnson D E
Urology. 1981 Nov;18(5):459-63. doi: 10.1016/0090-4295(81)90289-2.
One hundred nine patients with Stage O or A bladder cancer unmanageable transurethrally underwent radical cystectomy and ileal conduit urinary diversion without lymphadenectomy. Fifty-six were also given planned preoperative radiation therapy. Five-year survival rate was 76 per cent for the entire group. Irradiation eradicated all of the tumor (Po) in 36 per cent of patients, no patient Po after irradiation had recurrent disease, and local recurrence was noted in only 3.5 per cent of the irradiated patients compared with 9.4 per cent of those not irradiated. Urethral cancer was present in 9 per cent of our patients, a finding that does not support our previous impression that patients with multifocal bladder cancer or tumors involving the prostatic urethra had a higher than average incidence of urethral carcinoma.
109例无法经尿道处理的O期或A期膀胱癌患者接受了根治性膀胱切除术及回肠代膀胱术，未行淋巴结清扫。56例患者还接受了术前计划性放疗。整个组的5年生存率为76%。放疗使36%的患者肿瘤完全消失（P0），放疗后达到P0的患者无复发病例，放疗患者的局部复发率仅为3.5%，而未放疗患者为9.4%。9%的患者存在尿道癌，这一发现不支持我们之前的观点，即多灶性膀胱癌或累及前列腺尿道的肿瘤患者尿道癌的发病率高于平均水平。
