Department of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, Omaha, NE, U.S.A.
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.
Biochem Soc Trans. 2019 Dec 20;47(6):1679-1687. doi: 10.1042/BST20190113.
Myocardial Infarction (MI) initiates a series of wound healing events that begins with up-regulation of an inflammatory response and culminates in scar formation. The extracellular matrix (ECM) is intricately involved in all stages from initial break down of existing ECM to synthesis of new ECM to form the scar. This review will summarize our current knowledge on the processes involved in ECM remodeling after MI and identify the gaps that still need to be filled.
心肌梗死（MI）引发了一系列的创伤愈合事件，这些事件始于炎症反应的上调，并最终导致瘢痕形成。细胞外基质（ECM）在初始 ECM 降解到新 ECM 合成再到瘢痕形成的所有阶段都紧密参与。这篇综述将总结我们目前对 MI 后 ECM 重塑所涉及的过程的认识，并确定仍需填补的空白。
