Department of Urology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, South Korea.
Institute for Innovative Cancer Research, Asan Institute for Life Science, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Sci Rep. 2019 Nov 14;9(1):16794. doi: 10.1038/s41598-019-53280-5.
In total, 95 prostate cancer (Pca) patients who underwent transurethral resection of the prostate from 2000 to 2013 were assigned to four groups: Group 1, hormone-naïve and T1a or T1b Pca (n = 17); Group 2, hormone-sensitive and metastatic Pca (n = 33); Group 3, chemo-naïve castration-resistant Pca (CRPC), (n = 18); and Group 4, CRPC with chemotherapy (n = 27). Full-length androgen receptor (ARfl) transcript levels significantly increased from Group 1 through to Group 3 (p = 0.045), but decreased from Group 3 through to Group 4. AR splice variant 7 (ARV7) and glucocorticoid receptor (GR) transcript levels significantly increased from Group 1 through to Group 4 (p = 0.002 and 0.049, respectively). Kaplan-Meier curve revealed that the high transcript level of these three receptors resulted in significantly poorer cancer-specific survival (CSS) than that by low transcript level, although Cox regression analysis revealed that the ARV7 level alone was an independent prognostic factor for CSS in CRPC patients (high vs. low: hazard ratio, 1.897; 95% confidence interval, 1.102-3.625; p = 0.042). In conclusion, ARV7 and GR transcript levels significantly increase as Pca progresses to CRPC.
共有 95 例前列腺癌（Pca）患者于 2000 年至 2013 年接受经尿道前列腺切除术，将其分为四组：组 1，激素初治且肿瘤局限于 T1a 或 T1b（n=17）；组 2，激素敏感且发生转移的 Pca（n=33）；组 3，化疗初治的去势抵抗性前列腺癌（CRPC）（n=18）；组 4，接受化疗的 CRPC（n=27）。全长雄激素受体（ARfl）转录本水平从组 1 到组 3 显著增加（p=0.045），但从组 3 到组 4 降低。AR 剪接变异体 7（ARV7）和糖皮质激素受体（GR）转录本水平从组 1 到组 4 显著增加（p=0.002 和 0.049）。Kaplan-Meier 曲线表明，这三种受体的高转录本水平导致癌症特异性生存（CSS）明显低于低转录本水平，尽管 Cox 回归分析表明，在 CRPC 患者中，仅 ARV7 水平是 CSS 的独立预后因素（高 vs. 低：风险比，1.897；95%置信区间，1.102-3.625；p=0.042）。总之，随着前列腺癌进展为 CRPC，ARV7 和 GR 转录本水平显著增加。
