Box S J, Hood J D, Spear S R
J Antibiot (Tokyo). 1979 Dec;32(12):1239-47. doi: 10.7164/antibiotics.32.1239.
Four beta-lactam antibiotics with beta-lactamase inhibitory activity MM 22380, MM 22381, MM 22382 and MM 22383 containing the carbapenem nucleus have been isolated from a culture of Streptomyces olivaceus ATCC 31365. Fermentation conditions for their production and methods for their isolation are described. Evidence for a biosynthetic link between these compounds and the previously described olivanic acid derivatives MM 4550, MM 13902 and MM 17880 is presented.
从橄榄色链霉菌ATCC 31365的培养物中分离出了四种具有β-内酰胺酶抑制活性、含有碳青霉烯核的β-内酰胺抗生素MM 22380、MM 22381、MM 22382和MM 22383。描述了它们的生产发酵条件及其分离方法。还提供了这些化合物与先前描述的奥利万酸衍生物MM 4550、MM 13902和MM 17880之间生物合成联系的证据。
