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小儿心脏移植的获取、列入名单及监管中的伦理问题。

Ethical issues in access, listing and regulation of pediatric heart transplantation.

作者信息

Bearl David W

机构信息

Thomas P. Graham Jr. Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.

出版信息

Transl Pediatr. 2019 Oct;8(4):278-283. doi: 10.21037/tp.2019.08.01.

DOI:10.21037/tp.2019.08.01
PMID:31728320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6825968/
Abstract

Organ scarcity often drives ethical discussion in pediatric heart transplantation. There are questions about autonomy and equity in the referral patterns. There are questions about beneficence in how referral centers are established and operate. There are questions about fairness in how patients are listed and evaluated for listing exceptions. Finally, there are questions about beneficence, maleficence, and justice when it comes to the regulatory oversight of transplantation. This review will serve as a brief review of some of the more pressing ethical matters in pediatric heart transplantation and, where possible, offer potential solutions.

摘要

器官稀缺常常引发小儿心脏移植领域的伦理讨论。在转诊模式方面存在关于自主权和平等性的问题。在转诊中心的设立和运营方式上存在关于行善原则的问题。在患者列入名单以及评估名单例外情况时存在关于公平性的问题。最后,在移植的监管方面存在关于行善、作恶和公正的问题。本综述将简要回顾小儿心脏移植中一些较为紧迫的伦理问题,并在可能的情况下提供潜在解决方案。

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本文引用的文献

1
Geographic Distance From Transplant Center Does Not Impact Pediatric Heart Transplant Outcomes.与移植中心的地理距离不影响小儿心脏移植结果。
Prog Transplant. 2018 Jun;28(2):170-173. doi: 10.1177/1526924818765811. Epub 2018 Mar 20.
2
Inferior Outcomes on the Waiting List in Low-Volume Pediatric Heart Transplant Centers.低容量儿科心脏移植中心的候补名单上的不良结果。
Am J Transplant. 2017 Jun;17(6):1515-1524. doi: 10.1111/ajt.14252. Epub 2017 Mar 30.
3
The impact of cognitive delay on pediatric heart transplant outcomes.认知延迟对小儿心脏移植结局的影响。
Pediatr Transplant. 2017 Mar;21(2). doi: 10.1111/petr.12896.
4
Urgent listing exceptions and outcomes in pediatric heart transplantation: Comparison to standard criteria patients.儿科心脏移植中的紧急名单例外情况和结果:与标准标准患者的比较。
J Heart Lung Transplant. 2017 Mar;36(3):280-288. doi: 10.1016/j.healun.2016.09.007. Epub 2016 Oct 1.
5
Regional variation in the use of 1A status exceptions for pediatric heart transplant candidates: is this equitable?儿科心脏移植候选者1A状态例外情况使用的地区差异:这公平吗?
Pediatr Transplant. 2017 Feb;21(1). doi: 10.1111/petr.12784. Epub 2016 Aug 23.
6
Is it time for a national pediatric heart review board?是时候设立一个全国性的儿科心脏审查委员会了吗?
Clin Transplant. 2016 Oct;30(10):1365. doi: 10.1111/ctr.12799. Epub 2016 Aug 21.
7
Adverse events in children implanted with ventricular assist devices in the United States: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS).美国植入心室辅助装置儿童的不良事件:来自儿童机械循环支持跨机构注册中心(PediMACS)的数据。
J Heart Lung Transplant. 2016 May;35(5):569-77. doi: 10.1016/j.healun.2016.03.005. Epub 2016 Mar 17.
8
The ethics of organ transplantation: a brief history.器官移植伦理:简史
Virtual Mentor. 2012 Mar 1;14(3):264-8. doi: 10.1001/virtualmentor.2012.14.3.mhst1-1203.
9
How small is too small? A systematic review of center volume and outcome after cardiac transplantation.多小算太小?心脏移植后中心容量与结局的系统评价。
Circ Cardiovasc Qual Outcomes. 2012 Nov;5(6):783-90. doi: 10.1161/CIRCOUTCOMES.112.966630. Epub 2012 Nov 6.
10
Prospective trial of a pediatric ventricular assist device.前瞻性儿科心室辅助装置试验。
N Engl J Med. 2012 Aug 9;367(6):532-41. doi: 10.1056/NEJMoa1014164.