Bel Hadj Imen, Boukhris Riadh, Khalsi Fatma, Namouchi Manel, Bougmiza Iheb, Tinsa Faten, Hamouda Samia, Boussetta Khadija
Tunis Med. 2019 Mar;97(3):455-460.
Due to the marked decline of maternal-fetal rhesus incompatibility, ABO alloimmunization has become the leading cause of the newborn hemolytic disease. It is estimated that 15-25 % of all pregnancies are concerned by ABO incompatibility.
Neonatal blood group B seems to be more predisposing to acute hemolysis and severe hyperbilirubinemia. We propose to find if the newborn's blood group B represents a risk factor for severe hemolysis and/or severe hyperbilirubinemia.
We conducted a comparative study in the pediatrics department "B" of the Children Hospital of Tunis. We collected retrospectively the medical files of the newborn hospitalized for ABO alloimmunization (January 2011 - March 2014), then we compared two groups, OA group with OA alloimmunization and OB group with OB alloimmunization. A significant threshold was fixed to 0.05.
We collected 98 cases of newborn ABO hemolytic disease. Both groups, OA and OB, were similar for the onset of jaundice, age of hospitalization, initial hemoglobin and indirect bilirubin levels. There were no statistically significant difference in the severity of hyperbilirubinemia and the use of exchange transfusion for the two groups. However, transfusion was statistically more frequent in the OB group compared to OA group (81.6‰ vs 10.2‰, p = 0,039, OR=2.9, 95% IC (1.1 - 7.8)).
OB alloimmunization seems to induce more active hemolysis than OA one, with no difference for severe hyperbilirubinemia in both groups.
由于母胎恒河猴血型不相容性显著下降，ABO血型同种免疫已成为新生儿溶血病的主要原因。据估计，所有妊娠中有15%-25%与ABO血型不相容有关。
新生儿B血型似乎更易发生急性溶血和严重高胆红素血症。我们旨在探究新生儿B血型是否是严重溶血和/或严重高胆红素血症的危险因素。
我们在突尼斯儿童医院的儿科“B”进行了一项比较研究。回顾性收集2011年1月至2014年3月因ABO血型同种免疫住院的新生儿病历，然后比较两组，即OA血型同种免疫组（OA组）和OB血型同种免疫组（OB组）。显著阈值设定为0.05。
我们收集了98例新生儿ABO溶血病病例。OA组和OB组在黄疸出现时间、住院年龄、初始血红蛋白和间接胆红素水平方面相似。两组在高胆红素血症严重程度和换血治疗使用情况方面无统计学显著差异。然而，与OA组相比，OB组输血在统计学上更频繁（81.6‰对10.2‰，p = 0.039，OR = 2.9，95%置信区间(1.1 - 7.8)）。
OB血型同种免疫似乎比OA血型同种免疫诱导更活跃的溶血，两组在严重高胆红素血症方面无差异。
