韩国孕妇恒河猴血型作为不良妊娠结局危险因素的评估：一项全国健康保险数据库研究
Evaluation of maternal rhesus blood type as a risk factor in adverse pregnancy outcomes in Korea: a nationwide health insurance database study.
作者信息
Jin Yihua, Dong Meari, Yang Seung Woo, Lee Kyu-Min, Han Sung Won, Seo Shin Hee, Lee Ajin, Sohn In Sook, Kwon Han Sung, Cho Geum Joon, Hwang Han Sung
机构信息
Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea.
School of Industrial Management Engineering, Korea University, Seoul, Korea.
出版信息
Obstet Gynecol Sci. 2020 Jul;63(4):448-454. doi: 10.5468/ogs.20004. Epub 2020 Jul 1.
OBJECTIVES
The current study aimed to investigate whether pregnancy outcomes are affected by maternal rhesus (Rh) status by comparing the primigravida pregnancy outcomes of Rh-negative women with those of Rh-positive women.
METHODS
The study data were collected from the Korea National Health Insurance Claims Database and the National Health Screening Program for Infants and Children. In total, 1,664,882 primigravida women who gave birth between January 1, 2007 and December 31, 2014, were enrolled in this study. As the risk and severity of sensitization response increases with each subsequent pregnancy, only primigravida women were enrolled. The patients were divided into 2 groups according to Rh status, and the pregnancy outcomes were compared.
RESULTS
In total, 1,661,320 women in the Rh-positive group and 3,290 in the Rh-negative group were assessed. With regard to adverse pregnancy outcomes, there was no statistically significant difference between the 2 groups in terms of the prevalence of preeclampsia, postpartum hemorrhage, abruptio placenta, placenta previa, and uterine artery embolization. A univariate analysis revealed that none of the adverse pregnancy outcomes were significantly correlated to Rh status (preeclampsia: odds ratio [OR], 1.00, 95% confidence interval [CI], 0.81-1.23; postpartum hemorrhage: OR, 1.10, 95% CI, 0.98-1.24; abruptio placenta: OR, 0.80, 95% CI, 0.46-1.37; and placenta previa: OR, 1.08, 95% CI, 0.78-1.42). The adjusted ORs of postpartum hemorrhage and preterm birth did not significantly differ.
CONCLUSION
Maternal Rh status is not associated with adverse outcomes in primigravida women.
目的
本研究旨在通过比较Rh阴性初产妇与Rh阳性初产妇的妊娠结局，探讨母亲的恒河猴血型（Rh）状态是否会影响妊娠结局。
方法
研究数据来自韩国国民健康保险索赔数据库以及国家婴幼儿健康筛查项目。本研究共纳入了2007年1月1日至2014年12月31日期间分娩的1,664,882名初产妇。由于致敏反应的风险和严重程度会随着后续每次妊娠而增加，因此仅纳入初产妇。根据Rh状态将患者分为两组，并比较妊娠结局。
结果
共评估了Rh阳性组的1,661,320名女性和Rh阴性组的3,290名女性。关于不良妊娠结局，两组在子痫前期、产后出血、胎盘早剥、前置胎盘和子宫动脉栓塞的发生率方面无统计学显著差异。单因素分析显示，所有不良妊娠结局均与Rh状态无显著相关性（子痫前期：比值比[OR]，1.00，95%置信区间[CI]，0.81 - 1.23；产后出血：OR，1.10，95% CI，0.98 - 1.24；胎盘早剥：OR，0.80，95% CI，0.46 - 1.37；前置胎盘：OR，1.08，95% CI，0.78 - 1.42）。产后出血和早产的校正OR无显著差异。
结论
母亲的Rh状态与初产妇的不良结局无关。
Zotero 插件