Department of Neurosurgery, Leiden University Medical Centre, Leiden, the Netherlands.
Department of Neurosurgery, Leiden University Medical Centre, Leiden, the Netherlands.
Spine J. 2020 May;20(5):754-764. doi: 10.1016/j.spinee.2019.11.002. Epub 2019 Nov 13.
The contribution of Modic changes (MCs) in relation to spinal pain and degenerative changes has been evaluated frequently. However, most studies focus on lumbar spine. The association between MCs, neck pain, and cervical disc degeneration is not clear.
The objective of this study was to review current literature on the association between MCs, cervical disc degeneration, and neck pain.
A systematic review METHODS: A literature search was performed in PubMed, Embase, and Web of Science using a sensitive search string combination. Studies were selected by predefined selection criteria and risk of bias was assessed using a validated Cochrane Checklist adjusted for this purpose.
Fourteen articles that associated MCs with neck pain and/or cervical disc degeneration were included in the present study. Ten articles showed low risk of bias and four showed intermediate risk of bias. The prevalence of MCs in cervical spine varied from 5% to 40% and type II was predominant. Patients with MCs were reported to experience more neck pain and disability. Cervical disc degeneration was detected more frequently in patients with MCs.
Modic changes were found to be associated with neck pain and with disc degeneration. Therefore, the large variation in prevalence that is reported is highly dependent on the nature of the studied population.
Modic 改变（MCs）与脊柱疼痛和退行性改变的关系已经被频繁评估。然而，大多数研究都集中在腰椎。MCs、颈部疼痛和颈椎间盘退变之间的关联尚不清楚。
本研究旨在回顾 MCs、颈椎间盘退变和颈部疼痛之间关联的现有文献。
系统评价
使用敏感的搜索字符串组合，在 PubMed、Embase 和 Web of Science 中进行文献检索。通过预先设定的选择标准选择研究，并使用为此目的调整的经过验证的 Cochrane 清单评估偏倚风险。
本研究共纳入了 14 篇与 MCs 与颈部疼痛和/或颈椎间盘退变相关的文章。10 篇文章的偏倚风险较低，4 篇文章的偏倚风险为中等。颈椎 MCs 的患病率从 5%到 40%不等，II 型居多。患有 MCs 的患者报告颈部疼痛和残疾更为严重。在 MCs 患者中，颈椎间盘退变更为常见。
MCs 与颈部疼痛和椎间盘退变有关。因此，报告的患病率的巨大差异高度依赖于研究人群的性质。
