Ferraro Valentina Agnese, Zanconato Stefania, Baraldi Eugenio, Carraro Silvia
Women's and Children's Health Department, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
J Clin Med. 2019 Oct 25;8(11):1783. doi: 10.3390/jcm8111783.
In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described the main biological mediators that have been studied in pediatric CRS and asthma, and, according to the available literature, we reported their potential role in the diagnosis and management of these conditions. As for CRS, we discussed the studies that investigated nasal nitric oxide (nNO), pendrin, and periostin. As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs).
Among non-invasive biomarkers, nNO seems the most informative in CRS and feNO in asthma. Other biological mediators seem promising, but further studies are needed before they can be applied in clinical practice.
在所谓的统一气道理论背景下，慢性鼻-鼻窦炎（CRS）和哮喘可能并存。这些疾病的潜在炎症可通过生物标志物进行研究。
我们描述了在儿童CRS和哮喘中已被研究的主要生物介质，并根据现有文献，报告了它们在这些疾病的诊断和管理中的潜在作用。对于CRS，我们讨论了研究鼻一氧化氮（nNO）、pendrin和骨膜蛋白的研究。对于哮喘，我们讨论了呼出气一氧化氮分数（feNO）的作用、骨膜蛋白的作用以及在呼出气冷凝液（EBC）和呼出气体（挥发性有机化合物，VOCs）中测量的生物介质的作用。
在非侵入性生物标志物中，nNO似乎是CRS中最具信息量的，而feNO在哮喘中最具信息量。其他生物介质似乎很有前景，但在它们能够应用于临床实践之前还需要进一步研究。
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