Department of Ophthalmology, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea.
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.
Ophthalmology. 2020 Mar;127(3):417-425. doi: 10.1016/j.ophtha.2019.09.032. Epub 2019 Sep 27.
To determine the age- and sex-specific prevalence and incidence of demyelinating optic neuritis and the risk of multiple sclerosis (MS) in pediatric and adult populations in South Korea.
A nationwide, population-based, retrospective study using data from the Korean National Health Claims database from 2010 to 2016.
The entire South Korean population aged 65 years of age or younger (n = 44 700 564). All patients with optic neuritis from the entire Korean population were included.
Patients aged 14 years of age or younger were classified as pediatric patients, and those aged 15 to 65 years were classified as adults. Each group was analyzed separately. Patients with optic neuritis had a subsequent diagnosis, including idiopathic, MS, neuromyelitis optica (NMO), and acute disseminated encephalomyelitis. Prevalence and incidence, conversion rate to MS, and treatment modalities (steroids, plasmapheresis, interferon-β, and immunosuppressants) were estimated.
Prevalence and incidence of optic neuritis, and conversion rate to MS.
Among 44 700 564 individuals, 531 pediatric patients (50.7% female) and 7183 adults (53.3% female) were identified as having optic neuritis. Annual incidence was 1.04 (95% confidence interval [CI], 1.01-1.07) per 100 000 pediatric individuals and 3.29 (95% CI, 3.28-3.30) per 100 000 adults. Peak incidence was observed at 10 to 14 years in the pediatric population and at 30 to 34 years and 50 to 54 years in the adult population. Conversion rate to MS was 13.8% in the pediatric population and 11.4% in the adult population. Fourteen percent of all patients were treated with chronic immunosuppressants, 38% of patients with NMO underwent plasmapheresis, and 50% of patients with MS were treated with interferon-β.
This is a nationwide epidemiologic study of optic neuritis in individuals of all ages in South Korea. The incidence of optic neuritis and subsequent risk of MS in the pediatric population are comparable to those reported in western countries but are lower in the adult population than in western countries. The incidence rate in adults was 3.2-fold higher than in the pediatric population, and the overall MS conversion rate in the entire Korean population was estimated to be 10.6%.
确定韩国儿科和成年人群中脱髓鞘性视神经炎的年龄和性别特异性患病率和发病率，以及多发性硬化症（MS）的发病风险。
一项全国性、基于人群的回顾性研究，使用了 2010 年至 2016 年韩国国家健康索赔数据库的数据。
年龄在 65 岁及以下的全体韩国人口（n=44700564 人）。纳入了所有来自全体韩国人口的视神经炎患者。
年龄在 14 岁及以下的患者被归类为儿科患者，年龄在 15 至 65 岁的患者被归类为成年患者。分别对每组进行分析。患有视神经炎的患者有后续诊断，包括特发性、MS、视神经脊髓炎（NMO）和急性播散性脑脊髓炎。估计了患病率和发病率、向 MS 的转化率，以及治疗方式（类固醇、血浆置换、干扰素-β 和免疫抑制剂）。
视神经炎的患病率和发病率，以及向 MS 的转化率。
在 44700564 人中，发现 531 名儿科患者（50.7%为女性）和 7183 名成年患者（53.3%为女性）患有视神经炎。儿科人群的年发病率为 1.04（95%置信区间[CI]，1.01-1.07）/100000 人，成年人群的年发病率为 3.29（95%CI，3.28-3.30）/100000 人。儿科人群的发病高峰在 10 至 14 岁，成年人群的发病高峰在 30 至 34 岁和 50 至 54 岁。儿科人群向 MS 的转化率为 13.8%，成年人群为 11.4%。所有患者中有 14%接受了慢性免疫抑制剂治疗，38%的 NMO 患者接受了血浆置换，50%的 MS 患者接受了干扰素-β治疗。
这是一项针对韩国各年龄段人群视神经炎的全国性流行病学研究。儿科人群中视神经炎的发病率和随后发生 MS 的风险与西方国家报道的相似，但成年人群中的发病率低于西方国家。成人的发病率是儿科人群的 3.2 倍，整个韩国人群的总体 MS 转化率估计为 10.6%。
