Anokhina I P, Anokhin P K, Kokhan V S
Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia.
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Dokl Biol Sci. 2019 Sep;488(1):133-135. doi: 10.1134/S0012496619050016. Epub 2019 Nov 15.
C/EBP-β, a basic leucine zipper transcription factor, has important roles in the regulation of the body immune and inflammatory responses. Wistar rats subjected to combined irradiation were characterized by an increase in the content of the C/EBP-β LIP isoform in the pituitary gland. The obtained data indicate that moderate doses of ionizing radiation to initiate the endoplasmic reticulum stress response and are likely to initiate C/EBP-β-mediated cell death according to the apoptotic scenario. This study also confirms the earlier hypothesis about the alterations of the hypothalamic-pituitary-adrenocortical axis in response to moderate doses of ionizing radiation.
C/EBP-β是一种碱性亮氨酸拉链转录因子，在机体免疫和炎症反应的调节中发挥重要作用。接受联合照射的Wistar大鼠的特征是垂体中C/EBP-β LIP亚型的含量增加。所得数据表明，中等剂量的电离辐射会引发内质网应激反应，并可能根据凋亡情况引发C/EBP-β介导的细胞死亡。本研究还证实了先前关于下丘脑-垂体-肾上腺皮质轴在中等剂量电离辐射作用下发生改变的假说。
