Patterson Kira, Beers Jeanette, Linask Kaari L, Lin Yongshun, Hassanzadeh Shahin, Sack Michael N, Zou Jizhong
iPSC Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Stem Cell Res. 2019 Dec;41:101627. doi: 10.1016/j.scr.2019.101627. Epub 2019 Nov 1.
Human-derived induced pluripotent stem cells (iPSCs) have proven to be indispensable in cardiovascular drug development, disease modeling, and developmental biology research. For this reason, it is particularly useful to develop wild-type iPSC lines to be used in experimental or control conditions. Here, we present two such cell lines generated from a sample of peripheral blood mononuclear cells (PBMCs) from a healthy patient with normal cardiac function.
人源诱导多能干细胞（iPSC）已被证明在心血管药物开发、疾病建模和发育生物学研究中不可或缺。因此，开发用于实验或对照条件的野生型iPSC系特别有用。在此，我们展示了从一名心脏功能正常的健康患者的外周血单个核细胞（PBMC）样本中产生的两个这样的细胞系。
