Division of Critical Care Medicine, Children's National Medical Center, 111 Michigan Avenue Northwest, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine, Washington, DC, USA.
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati Children's Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Crit Care Clin. 2020 Jan;36(1):89-104. doi: 10.1016/j.ccc.2019.08.007.
Biomarker panels have the potential to advance the field of critical care medicine by stratifying patients according to prognosis and/or underlying pathophysiology. This article discusses the discovery and validation of biomarker panels, along with their translation to the clinical setting. The current literature on the use of biomarker panels in sepsis, acute respiratory distress syndrome, and acute kidney injury is reviewed.
生物标志物组合有可能通过根据预后和/或潜在病理生理学对患者进行分层来推动重症监护医学领域的发展。本文讨论了生物标志物组合的发现和验证，以及它们在临床环境中的转化。本文回顾了生物标志物组合在脓毒症、急性呼吸窘迫综合征和急性肾损伤中的应用的现有文献。
