Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Med Chem. 2024;31(41):6801-6825. doi: 10.2174/0929867331666230726095222.
The use of biomarkers to expedite diagnosis, prognostication, and treatment could significantly improve patient outcomes. The early diagnosis and treatment of critical illnesses can greatly reduce mortality and morbidity. Therefore, there is great interest in the discovery of biomarkers for critical illnesses. Micro-ribonucleic acids (miRNAs) are a highly conserved group of non-coding RNA molecules. They regulate the expression of genes involved in several developmental, physiological, and pathological processes. The characteristics of miRNAs suggest that they could be versatile biomarkers. Assay panels to measure the expression of several miRNAs could facilitate clinical decision-- making for a range of diseases. We have, in this paper, reviewed the current understanding of the role of miRNAs as biomarkers in critically ill patients.
生物标志物的应用可以加速诊断、预后和治疗，从而显著改善患者的结局。危重病的早期诊断和治疗可以大大降低死亡率和发病率。因此，人们对发现危重病的生物标志物非常感兴趣。微小 RNA（miRNAs）是一组高度保守的非编码 RNA 分子。它们调节参与多种发育、生理和病理过程的基因的表达。miRNAs 的特点表明它们可能是多功能的生物标志物。测量几种 miRNA 表达的检测试剂盒可以为一系列疾病的临床决策提供便利。在本文中，我们回顾了 miRNA 作为危重病患者生物标志物的作用的现有认识。
