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来自飞扬大戟茎部的两种新酚类成分。

Two New Phenolic Constituents from the Stems of Euphorbia griffithii.

作者信息

Kaunda Joseph Sakah, Zhang Ying-Jun

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People's Republic of China.

Graduate School of the Chinese Academy of Sciences, Beijing, 100039, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2019 Dec;9(6):405-410. doi: 10.1007/s13659-019-00223-2. Epub 2019 Nov 16.

DOI:10.1007/s13659-019-00223-2
PMID:31734865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6872693/
Abstract

Phytochemical studies on MeOH extract of stems of Euphorbia griffithii led to the isolation of one new hydrolyzable tannin dimer, corilagiffithiin (1) and one new galloyl-glucoside (2), alongside six known ones (3-8). Their structures and absolute configurations were determined by in depth spectroscopic analyses and comparison of their 1D NMR and MS data with literature reported values. Configurations of sugar moieties were determined by acidic hydrolysis and subsequent GC analysis of their corresponding trimethylsilylated L-cysteine adduct. At a concentration of 50 μM, compounds 1-3 showed no anti-inflammatory activities.

摘要

对大戟科大戟属植物粗茎大戟甲醇提取物进行的植物化学研究，分离得到一种新的可水解单宁二聚体——大戟粗茎素（1）和一种新的没食子酰葡萄糖苷（2），以及六种已知化合物（3 - 8）。通过深入的光谱分析，并将它们的一维核磁共振谱和质谱数据与文献报道值进行比较，确定了它们的结构和绝对构型。糖部分的构型通过酸性水解及其相应的三甲基硅烷基化L - 半胱氨酸加合物的后续气相色谱分析来确定。在浓度为50 μM时，化合物1 - 3没有显示出抗炎活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2651/6872693/659aef37972e/13659_2019_223_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2651/6872693/5db6c6c58a50/13659_2019_223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2651/6872693/659aef37972e/13659_2019_223_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2651/6872693/5db6c6c58a50/13659_2019_223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2651/6872693/659aef37972e/13659_2019_223_Fig2_HTML.jpg

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