TAAR1 激动剂 RO5263397 对大鼠执行功能的作用。
The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats.
机构信息
Valdman Institute of Pharmacology, Pavlov First St. Petersburg State Medical University, Lev Tolstoy str. 6-8, St. Petersburg, Russia, 197022.
Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya Emb. 7-9, St. Petersburg, Russia, 199034.
出版信息
Cell Mol Neurobiol. 2020 Mar;40(2):215-228. doi: 10.1007/s10571-019-00757-6. Epub 2019 Nov 16.
Abstract
Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.
摘要
追踪胺相关受体 1（TAAR1）是神经精神药理学治疗的一个广受认可的新视角靶点。尽管越来越多的研究调查了 TAAR1 在不同病理动物模型中的作用，但关于 TAAR1 激动剂对执行认知功能影响的信息有限。本研究的目的是评估高选择性部分 TAAR1 激动剂 RO5263397 对各种执行认知功能的作用。本研究的结果表明，RO5263397 的预处理能够增加大鼠的注意力并降低认知灵活性。对 TAAR1 激活作用于冲动性的分析表明，TAAR1 的激活不能影响过早反应，但能够轻微改变冲动性选择。解决问题不受药物干预的影响。
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