Department of Pharmacology and Toxicology, University At Buffalo, The State University of New York, 955 Main Street, Buffalo, NY, 14214, USA.
Medical College of Yangzhou University, Yangzhou, China.
Psychopharmacology (Berl). 2021 Nov;238(11):3221-3228. doi: 10.1007/s00213-021-05937-1. Epub 2021 Jul 22.
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that has a particular role in regulating dopaminergic, serotonergic, and glutamatergic transmission. TAAR1 agonists have shown pro-cognitive activities. However, it remains largely unknown of the effects of TAAR1 agonists on memory performance.
Here, by using the mice novel object recognition (NOR) test, we examined the effects of the selective TAAR1 partial agonist RO5263397 on recognition memory.
We found that RO5263397 significantly enhanced the retrieval of short-term memory (STM; 20 min after training) both in male and female mice. RO5263397 promoted the retrieval of STM in the wild-type (WT) littermates but not TAAR1-KO mice, indicating that the effects of RO5263397 were dependent on TAAR1. Interestingly, compared to their WT litters, TAAR1-KO mice showed similar levels of STM, suggesting that genetic deletion of taar1 gene did not affect the STM retrieval. Furthermore, RO5263397 also promoted the retrieval of long-term NOR memory (24 h after training).
These results indicate that TAAR1 activation promotes NOR memory retrieval. Consistent with previous studies, our finding further suggests that TAAR1 agonists have pro-cognitive properties.
痕量胺相关受体 1（TAAR1）是一种 G 蛋白偶联受体，在调节多巴胺能、血清素能和谷氨酸能传递方面具有特殊作用。TAAR1 激动剂具有促认知活性。然而，TAAR1 激动剂对记忆表现的影响在很大程度上仍然未知。
在这里，我们通过使用小鼠新物体识别（NOR）测试，研究了选择性 TAAR1 部分激动剂 RO5263397 对记忆表现的影响。
我们发现 RO5263397 显著增强了雄性和雌性小鼠的短期记忆（STM；在训练 20 分钟后）的检索。RO5263397 促进了 WT 同窝仔鼠的 STM 检索，但在 TAAR1-KO 小鼠中没有，表明 RO5263397 的作用依赖于 TAAR1。有趣的是，与 WT 同窝仔鼠相比，TAAR1-KO 小鼠表现出相似的 STM 水平，表明 taar1 基因的遗传缺失不会影响 STM 检索。此外，RO5263397 还促进了长时 NOR 记忆的检索（在训练 24 小时后）。
这些结果表明 TAAR1 的激活促进了 NOR 记忆的检索。与先前的研究一致，我们的发现进一步表明 TAAR1 激动剂具有促认知特性。
