De Jaeghere Emiel A, Denys Hannelore G, De Wever Olivier
Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Medical Oncology, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium; Gynecologic Pelvic Oncology Network Ghent (GYPON), Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Medical Oncology, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium; Gynecologic Pelvic Oncology Network Ghent (GYPON), Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Trends Cancer. 2019 Nov;5(11):704-723. doi: 10.1016/j.trecan.2019.09.009. Epub 2019 Oct 29.
Immune escape is central to the persistence of most, if not all, solid tumors and poses a critical obstacle to successful cancer (immuno)therapy. Cancer-associated fibroblasts (CAFs) constitute the most prevalent, yet heterogeneous, component of the tumor stroma, where they 'cool down' the immune microenvironment. The central role played by CAFs, both as a physical barrier and source of immunosuppressive molecules, sets them as a target to enhance immunotherapy of cancer. We outline the current understanding of how CAFs fuel immune escape, as well as their potential clinical applications. Whether these therapeutics really have clinically significant activity remains to be seen, but the outlook is positive.
免疫逃逸是大多数（即便不是全部）实体瘤持续存在的核心问题，也是成功进行癌症（免疫）治疗的关键障碍。癌症相关成纤维细胞（CAF）是肿瘤基质中最普遍但也最为异质的成分，它们会使免疫微环境“降温”。CAF作为物理屏障和免疫抑制分子来源所发挥的核心作用，使其成为增强癌症免疫治疗的靶点。我们概述了目前对CAF如何促进免疫逃逸的理解及其潜在的临床应用。这些疗法是否真的具有临床显著活性还有待观察，但前景是乐观的。
