Wen Chao Liang, Sun Cong Jiao, Yang Ning
National Engineering Laboratory for Animal Breeding, College of Animal Science andTechnology, China Agricultural University, Beijing100193, China.
Yi Chuan. 2019 Nov 20;41(11):1023-1040. doi: 10.16288/j.yczz.19-130.
Heritability, one of the central quantitative genetic parameters, is critically important to measure the genetic variation of traits, especially in the studies of the response to selection in evolutionary biology and agriculture, and the prediction of disease risks in medicine. The statistical model and method for estimating heritability have been continually developed and improved, since the genetic variance components was first proposed by Fisher in 1918. Recently, the term "microbiability" (m ), an analogous concept and estimated method to heritability, was introduced in gut microbiome research for evaluating the effect of entire microbiota on a host phenotype. In this review, we summarize the progress of statistical methods in the heritability estimation, as well as the current state of gut microbiome associations with the host genome, with a particular focus on the concept and estimated methods of microbiability. Our review will provide a reference for the future study of host phenotypic variation that can be inferred by the gut microbiota.
遗传力作为核心数量遗传参数之一，对于衡量性状的遗传变异至关重要，尤其在进化生物学和农业中对选择反应的研究以及医学中疾病风险的预测方面。自1918年费希尔首次提出遗传方差成分以来，估计遗传力的统计模型和方法一直在不断发展和完善。最近，“微生物遗传力”（m）这一与遗传力类似的概念和估计方法被引入肠道微生物组研究，用于评估整个微生物群对宿主表型的影响。在本综述中，我们总结了遗传力估计统计方法的进展，以及肠道微生物组与宿主基因组关联的现状，特别关注微生物遗传力的概念和估计方法。我们的综述将为未来通过肠道微生物群推断宿主表型变异的研究提供参考。
