鲜椰油及其馏分在肝癌和口腔癌细胞中的抗癌活性。
Anticancer Activity of Virgin Coconut Oil and its Fractions in Liver and Oral Cancer Cells.
机构信息
Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar-751019, India.
Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar-751019, India.
出版信息
Anticancer Agents Med Chem. 2019;19(18):2223-2230. doi: 10.2174/1871520619666191021160752.
BACKGROUND
Coconut oil is an edible oil obtained from fresh, mature coconut kernels. Few studies have reported the anticancer role of coconut oil. The fatty acid component of coconut oil directly targets the liver by portal circulation and as chylomicron via lymph. However, the anti-cancer activity of coconut oil against liver cancer cells and oral cancer cells is yet to be tested. The active component of coconut oil, that is responsible for the anticancer activity is not well understood. In this study, three different coconut oils, Virgin Coconut Oil (VCO), Processed Coconut Oil (PCO) and Fractionated Coconut Oil (FCO), were used.
OBJECTIVE
Based on previous studies, it can be hypothesized that fatty acids in coconut oil may have anticancer potential and may trigger cell death in cancer cell lines.
METHODS
Each cell line was treated with different concentrations of Virgin Coconut Oil (VCO), Processed Coconut Oil (PCO) and Fractionated Coconut Oil (FCO). The treated cells were assayed by MTT after 72 hr of incubation. The fatty acid composition of different coconut oils was analyzed by gas chromatography.
RESULT
Different concentrations of coconut oils were used to treat the cells. Interestingly, the anticancer efficacy of VCO, PCO and FCO was not uniform, rather the efficacy varied from cell line to cell line. Only 20% VCO showed significant anticancer activity in HepG2 cells in comparison to 80% PCO against the KB cell line. Remarkably, 20% of PCO and 5% of FCO showed potential growth inhibition in the KB cell line as compared to 80% PCO in HepG2 cells. Moreover, there was a difference in the efficacy of VCO, PCO and FCO, which might be due to their fatty acid composition. Comparing the anticancer efficacy of VCO, PCO and FCO in this study helped to predict which class of fatty acids and which fatty acid might be associated with the anticancer activity of VCO.
CONCLUSION
This study shows that VCO, PCO and FCO have anticancer efficacy and may be used for the treatment of cancer, especially liver and oral cancer.
背景
椰子油是从新鲜成熟的椰肉中提取的食用油。很少有研究报道椰子油的抗癌作用。椰子油的脂肪酸成分通过门静脉循环和乳糜微粒直接靶向肝脏。然而，椰子油对肝癌细胞和口腔癌细胞的抗癌活性尚未得到检验。椰子油中负责抗癌活性的活性成分还不是很清楚。在这项研究中，使用了三种不同的椰子油，即初榨椰子油（VCO）、加工椰子油（PCO）和分馏椰子油（FCO）。
目的
基于以往的研究，可以假设椰子油中的脂肪酸可能具有抗癌潜力，并可能引发癌细胞系的细胞死亡。
方法
用不同浓度的初榨椰子油（VCO）、加工椰子油（PCO）和分馏椰子油（FCO）处理每种细胞系。在孵育 72 小时后，通过 MTT 测定处理后的细胞。不同椰子油的脂肪酸组成通过气相色谱进行分析。
结果
用不同浓度的椰子油处理细胞。有趣的是，VCO、PCO 和 FCO 的抗癌效果并不一致，而是因细胞系而异。只有 20%的 VCO 在 HepG2 细胞中表现出显著的抗癌活性，而 80%的 PCO 对 KB 细胞系有效。值得注意的是，20%的 PCO 和 5%的 FCO 在 KB 细胞系中表现出潜在的生长抑制作用，而 80%的 PCO 在 HepG2 细胞中则没有。此外，VCO、PCO 和 FCO 的疗效存在差异，这可能与其脂肪酸组成有关。比较本研究中 VCO、PCO 和 FCO 的抗癌效果有助于预测哪一类脂肪酸和哪种脂肪酸可能与 VCO 的抗癌活性有关。
结论
本研究表明，VCO、PCO 和 FCO 具有抗癌功效，可用于治疗癌症，特别是肝癌和口腔癌。
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